Editing Quinoline (section)

== Synthesis ==
Quinolines are often synthesized from simple anilines using a number of [[name reaction|named reactions]].
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Going clockwise from top these are: 
* [[Combes quinoline synthesis]] using [[aniline]]s and β-di[[ketone]]s.
* [[Conrad-Limpach synthesis]] using [[aniline]]s and β-ketoesters.
* [[Doebner reaction]] using [[aniline]]s with an [[aldehyde]] and [[pyruvic acid]] to form quinoline-4-carboxylic acids
* [[Doebner-Miller reaction]] using [[aniline]]s and α,β-unsaturated [[carbonyl]] compounds.
* [[Gould-Jacobs reaction]] starting from an aniline and ethyl ethoxymethylenemalonate
* [[Skraup synthesis]] using [[ferrous sulfate]], [[glycerol]], [[aniline]], [[nitrobenzene]], and [[sulfuric acid]].

A number of other processes exist, which require specifically substituted anilines or related compounds:
* [[Camps quinoline synthesis]] using an o-acylaminoacetophenone and hydroxide
* [[Friedländer synthesis]] using [[2-Aminobenzaldehyde|2-aminobenzaldehyde]] and [[acetaldehyde]]
* [[Knorr quinoline synthesis]], using a  β-ketoanilide and sulfuric acid
* [[Niementowski quinoline synthesis]], using anthranilic acid and ketones
* [[Pfitzinger reaction]] using an [[isatin]] with base and a carbonyl compound to yield substituted quinoline-4-carboxylic acids
* [[Povarov reaction]] using an [[aniline]], a [[benzaldehyde]] and an activated [[alkene]]

Quinolines are reduced to [[tetrahydroquinoline]]s enantioselectively using several catalyst systems.<ref>Xu, L.; Lam, K. H.; Ji, J.; Wu, J.; Fan, Q.-H.; Lo, W.-H.; Chan, A. S. C. ''Chem. Commun.'' '''2005''', 1390.</ref><ref>Reetz, M. T.; Li, X. ''Chem. Commun.'' '''2006''', 2159.</ref>
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