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Reserpine
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==Adverse effects== At doses of less than 0.2 mg/day, reserpine has few adverse effects, the most common of which is nasal congestion.<ref name="pmid3350594">{{cite journal | vauthors = Curb JD, Schneider K, Taylor JO, Maxwell M, Shulman N | title = Antihypertensive drug side effects in the Hypertension Detection and Follow-up Program | journal = Hypertension | volume = 11 | issue = 3 Pt 2 | pages = II51-5 | date = March 1988 | pmid = 3350594 | doi = 10.1161/01.hyp.11.3_pt_2.ii51 | doi-access = free }}</ref> Reserpine can cause: nasal congestion, nausea, vomiting, weight gain, gastric intolerance, gastric ulceration (due to increased cholinergic activity in gastric tissue and impaired mucosal quality), stomach cramps and diarrhea. The drug causes hypotension and bradycardia and may worsen asthma. Congested nose and erectile dysfunction are other consequences of alpha-blockade.<ref name="Giannini">AJ Giannini, HR Black. Psychiatric, Psychogenic, and Somatopsychic Disorders Handbook. Garden City, NY. Medical Examination Publishing, 1978. Pg. 233. {{ISBN|0-87488-596-5}}.</ref> Central nervous system effects at higher doses (0.5 mg or higher) include drowsiness, dizziness, nightmares, Parkinsonism, general weakness and fatigue. <ref name="Barcelos 2010">{{cite journal | vauthors = Barcelos RC, Benvegnú DM, Boufleur N, Pase C, Teixeira AM, Reckziegel P, Emanuelli T, da Rocha JB, Bürger ME | title = Short term dietary fish oil supplementation improves motor deficiencies related to reserpine-induced parkinsonism in rats | journal = Lipids | volume = 46 | issue = 2 | pages = 143–9 | date = February 2011 | pmid = 21161603 | doi = 10.1007/s11745-010-3514-0 | s2cid = 4036935 }}</ref> High dose studies in rodents found reserpine to cause fibroadenoma of the breast and malignant tumors of the seminal vesicles among others. Early suggestions that reserpine causes breast cancer in women (risk approximately doubled) were not confirmed. It may also cause [[hyperprolactinemia]].<ref name="Giannini" /> Reserpine passes into [[breast milk]] and is harmful to breast-fed infants, and should therefore be avoided during breastfeeding if possible.<ref name="kidsgrowth">{{usurped|1=[https://archive.today/20070623011707/http://www.kidsgrowth.org/resources/articledetail.cfm?id=471 kidsgrowth.org Drugs and Other Substances in Breast Milk]}} Retrieved on June 19, 2009</ref> It may produce an excessive decline in blood pressure at doses needed for treatment of anxiety, depression, or psychosis.<ref>{{cite book| vauthors = Pinel JP |title=Biopsychology|date=2011|publisher=Allyn & Bacon|isbn=978-0-205-83256-9|edition=8th|location=Boston|pages=469}}</ref>
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