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Simvastatin
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==Contraindications== Simvastatin is [[Contraindication|contraindicated]] with pregnancy, breastfeeding, and liver disease.<ref name=Rxlist/> Pregnancy must be avoided while on simvastatin due to potentially severe birth defects. Patients cannot breastfeed while on simvastatin due to potentially disrupting the infant's lipid metabolism.<ref name=LactMed>{{cite web|title=Simvastatin|url=http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f?./temp/~5v9vCs:1|work=LactMed|publisher=U.S. National Library of Medicine|access-date=1 December 2012}}</ref> High doses of simvastatin are also contraindicated with the widely used antihypertensive [[amlodipine]].<ref name=FDAJun2011 /> A lower dose is also recommended in people taking the calcium channel blockers, [[verapamil]] and [[diltiazem]], as well as those taking [[amiodarone]].<ref name=MHRA>{{cite journal |title=Simvastatin: updated advice on drug interactions - updated contraindications | journal = Drug Safety Update | publisher = Government of the United Kingdom | date = August 2012 | volume = 6 | issue = 1 | page = S1 |url=https://www.gov.uk/drug-safety-update/simvastatin-updated-advice-on-drug-interactions|access-date=3 November 2015|url-status=live|archive-url=https://web.archive.org/web/20160127121710/https://www.gov.uk/drug-safety-update/simvastatin-updated-advice-on-drug-interactions|archive-date=27 January 2016}}</ref><ref>{{cite web | title=FDA Drug Safety Communication: Revised dose limitation for Zocor (simvastatin) when taken with amiodarone | website=U.S. [[Food and Drug Administration]] (FDA) | date=15 December 2011 | url=https://www.fda.gov/Drugs/DrugSafety/ucm283137.htm | archive-url=https://web.archive.org/web/20121126053459/https://www.fda.gov/Drugs/DrugSafety/ucm283137.htm | archive-date=26 November 2012 | url-status=dead | access-date=12 October 2019}}</ref>
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