Editing Suppository (section)

==Rectal suppositories==
[[File:Glycerin suppositories.jpg|right|thumb|[[Glycerin]] suppositories ([[laxative]])]]
In 1991, a study on suppository insertion in ''[[The Lancet]]'' found that the "torpedo" shape helps the device to travel internally, increasing its efficacy.<ref>{{cite journal | last = Abd-El-Maeboud | first = K. H. |author2=T. El-Naggar |author3=E. M. M. El-Hawi |author4=S. A. R. Mahmoud |author5=S. Abd-El-Hay | title = Rectal suppository: commonsense and mode of insertion | journal = The Lancet | volume = 338 | issue = 8770 | pages = 798–800  | date = 28 September 1991| doi = 10.1016/0140-6736(91)90676-G | pmid=1681170| s2cid = 23190075 }}</ref> The findings of this single study have been challenged as there is insufficient evidence on which to base clinical practice.<ref>{{cite journal
  | last =  Bradshaw
  | first = Ann
  | author2 = Lynda Price
  | title = Rectal suppository insertion: the reliability of the evidence as a basis for nursing practice
  | url = https://s3.amazonaws.com/academia.edu.documents/48198397/Rectal_suppository_insertion_the_reliabi20160820-21954-12vnm39.pdf?response-content-disposition=inline%3B%20filename%3DRectal_suppository_insertion_the_reliabi.pdf&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Credential=AKIAIWOWYYGZ2Y53UL3A%2F20200229%2Fus-east-1%2Fs3%2Faws4_request&X-Amz-Date=20200229T174503Z&X-Amz-Expires=3600&X-Amz-SignedHeaders=host&X-Amz-Signature=bba7b820f124c0dd1a70b15dd093db59f4037667e652a3d2bf0500900d2cbb6f
  | journal = Journal of Clinical Nursing
  | volume = 16
  | issue = 1
  | pages = 98–103
  | date = 20 December 2006
  | doi=10.1111/j.1365-2702.2005.01519.x
  | pmid=17181671| archive-url = https://web.archive.org/web/20200229174541/https://s3.amazonaws.com/academia.edu.documents/48198397/Rectal_suppository_insertion_the_reliabi20160820-21954-12vnm39.pdf?response-content-disposition=inline%3B%20filename%3DRectal_suppository_insertion_the_reliabi.pdf&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Credential=AKIAIWOWYYGZ2Y53UL3A%2F20200229%2Fus-east-1%2Fs3%2Faws4_request&X-Amz-Date=20200229T174503Z&X-Amz-Expires=3600&X-Amz-SignedHeaders=host&X-Amz-Signature=bba7b820f124c0dd1a70b15dd093db59f4037667e652a3d2bf0500900d2cbb6f
 | archive-date = 2020-02-29
 }}
</ref> Rectal suppositories are intended for localized or systemic action to relieve pain, constipation, irritation, inflammation, nausea and vomiting, fever, migraines, allergies, and sedation.<ref>{{Cite journal|last=Hua|first=Susan|date=2019-10-16|title=Physiological and Pharmaceutical Considerations for Rectal Drug Formulations|journal=Frontiers in Pharmacology|volume=10|pages=1196|doi=10.3389/fphar.2019.01196|issn=1663-9812|pmc=6805701|pmid=31680970|doi-access=free}}</ref><ref>{{Cite web|title=ANTIBIOTIC/ANESTHETIC/STEROID - RECTAL SUPPOSITORIES side effects, medical uses, and drug interactions.|url=https://www.medicinenet.com/antibioticanestheticsteroid-rectal/article.htm|access-date=2021-12-11|website=MedicineNet|language=en}}</ref> If they cause inflammation, chronic use of suppositories may cause [[rectal stricture]],<ref name="Ahmad 2021" >Ahmad, A; Krishnamurthy, P (June 2021). "[https://practicalgastro.com/2021/08/17/benign-rectal-strictures-a-review-article/ Benign Rectal Strictures: A Review Article]". ''Practical Gastroenterology.'' '''45''' (6): 16-33.</ref> but overall this is a safe method of drug delivery.<ref name="Gupta2007">{{cite journal |last1=Gupta |first1=PJ |title=Suppositories in anal disorders: a review. |journal=European Review for Medical and Pharmacological Sciences |date=May 2007 |volume=11 |issue=3 |pages=165–70 |pmid=17970232}}</ref> [[File:Panadol suppositories.jpg|right|thumb|Four 500 mg [[paracetamol]] suppositories]]