Editing Telithromycin (section)

== Mechanism of action ==
Telithromycin prevents [[Bacterium|bacteria]] from growing, by interfering with their [[Protein biosynthesis|protein synthesis]]. Telithromycin binds to the subunit [[50S]] of the bacterial [[ribosome]],<ref>{{cite journal | vauthors = Eyal Z, Matzov D, Krupkin M, Wekselman I, Paukner S, Zimmerman E, Rozenberg H, Bashan A, Yonath A | title = Structural insights into species-specific features of the ribosome from the pathogen Staphylococcus aureus | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 112 | issue = 43 | pages = E5805–E5814 | date = October 2015 | pmid = 26464510 | pmc = 4629319 | doi = 10.1073/pnas.1517952112 | doi-access = free | bibcode = 2015PNAS..112E5805E }}</ref> and blocks the progression of the growing polypeptide chain. Telithromycin has over 10 times higher affinity to the subunit 50S than erythromycin. In addition, telithromycin strongly bind simultaneously to two domains of  23S RNA of the 50 S ribosomal subunit, where older macrolides bind strongly only to one domain and weakly to the second domain. Like many other protein synthesis inhibitors, telithromycin can also inhibit the formation of ribosomal subunits 50S and [[30S]].