Editing Transversion (section)

== Spontaneous germline transversion ==
[[8-oxo-2'-deoxyguanosine]] (8-oxodG) is an oxidized derivative of [[deoxyguanosine]], and is one of the major products of [[DNA oxidation]]. During [[DNA replication]] in the germ line of mice, the oxidized base [[8-oxoguanine]] (8-oxoG) causes spontaneous and heritable G to T transversion mutations.<ref name="pmid24732879">{{cite journal |vauthors=Ohno M, Sakumi K, Fukumura R, Furuichi M, Iwasaki Y, Hokama M, Ikemura T, Tsuzuki T, Gondo Y, Nakabeppu Y |title=8-oxoguanine causes spontaneous de novo germline mutations in mice |journal=Sci Rep |volume=4 |pages=4689 |year=2014 |pmid=24732879 |pmc=3986730 |doi=10.1038/srep04689 |bibcode=2014NatSR...4E4689O }}</ref>  These mutations occur in different stages of the [[germ cell]] lineage and are distributed throughout the [[chromosome]]s.