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Vaccination
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===Vaccination versus inoculation=== The term "[[inoculation]]" is often used interchangeably with "vaccination." However, while related, the terms are not synonymous. Vaccination is treatment of an individual with an attenuated (i.e. less virulent) [[pathogen]] or other [[immunogen]], whereas inoculation, also called [[variolation]] in the context of [[smallpox]] prophylaxis, is treatment with unattenuated variola virus taken from a pustule or scab of a smallpox patient into the superficial layers of the skin, commonly the upper arm. Variolation was often done 'arm-to-arm' or, less effectively, 'scab-to-arm', and often caused the patient to become infected with smallpox, which in some cases resulted in severe disease.<ref>{{Cite web|url=http://web.uvic.ca/vv/student/smallpox/doctors/diff.html|title=The Smallpox Epidemic of 1862 (Victoria BC)--Doctors and Diagnosis|website=web.uvic.ca|access-date=29 September 2016|archive-date=2 February 2018|archive-url=https://web.archive.org/web/20180202203718/http://web.uvic.ca/vv/student/smallpox/doctors/diff.html|url-status=live}}</ref><ref>{{cite web |url=http://web.uvic.ca/vv/student/smallpox/doctors/diff.html |title=Doctors and diagnosis ''The difference between Vaccination and Inoculation'' |publisher=Web.uvic.ca |access-date=8 January 2014 |archive-date=2 February 2018 |archive-url=https://web.archive.org/web/20180202203718/http://web.uvic.ca/vv/student/smallpox/doctors/diff.html |url-status=live }}</ref> Vaccinations began in the late 18th century with the work of [[Edward Jenner]] and the smallpox vaccine.<ref>{{cite news |title=Edward Jenner β (1749β1823) |publisher=Sundaytimes.lk. |date=1 June 2008 |url=http://sundaytimes.lk/080601/FunDay/famous.html |access-date=28 July 2009 |archive-url=https://web.archive.org/web/20110926095825/http://sundaytimes.lk/080601/FunDay/famous.html |archive-date=26 September 2011 |url-status=dead }}</ref><ref>{{cite web |url=https://www.bbc.co.uk/history/historic_figures/jenner_edward.shtml |title=History β Edward Jenner (1749β1823) |publisher=BBC |access-date=1 March 2014 |archive-date=8 March 2021 |archive-url=https://web.archive.org/web/20210308032314/https://www.bbc.co.uk/history/historic_figures/jenner_edward.shtml |url-status=live }}</ref><ref>{{cite web|url=http://www.dinweb.org/dinweb/DINMuseum/Edward%20Jenner.asp|title=Edward Jenner β Smallpox and the Discovery of Vaccination|website=dinweb.org|access-date=22 April 2010|archive-url=https://web.archive.org/web/20100827080455/http://www.dinweb.org/dinweb/DINMuseum/Edward%20Jenner.asp|archive-date=27 August 2010|url-status=dead}}</ref>
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