Editing ABC transporter (section)

== Reversal of multi drug resistance ==
Drug resistance is a common clinical problem that occurs in patients with infectious diseases and in patients with cancer. [[Prokaryotic]] and [[eukaryotic]] microorganisms as well as neoplastic cells are often found to be resistant to drugs. MDR is frequently associated with overexpression of ABC transporters. Inhibition of ABC transporters by low-molecular weight compounds has been extensively investigated in cancer patients; however, the clinical results have been disappointing. Recently various [[RNAi]] strategies have been applied to reverse MDR in different tumor models and this technology is effective in reversing ABC-transporter-mediated MDR in cancer cells and is therefore a promising strategy for overcoming MDR by gene therapeutic applications. RNAi technology could also be considered for overcoming MDR in infectious diseases caused by microbial pathogens.<ref name= LageL>{{cite book | vauthors = Lage L| year=2009|chapter=ABC Transporters as Target for RNA Interference-mediated Reversal of Multidrug Resistance|title=ABC Transporters in Microorganisms|publisher=Caister Academic |isbn= 978-1-904455-49-3}}</ref>