Editing Cluster headache (section)

===Opioids===
The use of [[opioid]] medication in management of cluster headache is not recommended<ref name=Pae2008/> and may make headache syndromes worse.<ref>{{cite journal |doi=10.1177/0333102412467512 |pmid=23144180 |title=Medication-overuse headache and opioid-induced hyperalgesia: A review of mechanisms, a neuroimmune hypothesis and a novel approach to treatment |journal=Cephalalgia |volume=33 |issue=1 |pages=52–64 |year=2012 |last1=Johnson |first1=Jacinta L |last2=Hutchinson |first2=Mark R |last3=Williams |first3=Desmond B |last4=Rolan |first4=Paul |s2cid=5697283 |hdl=2440/78280 |hdl-access=free }}</ref><ref>{{cite journal |doi=10.1016/j.tips.2009.08.002 |pmid=19762094 |pmc=2783351 |title=The "Toll" of Opioid-Induced Glial Activation: Improving the Clinical Efficacy of Opioids by Targeting Glia |journal=Trends in Pharmacological Sciences |volume=30 |issue=11 |pages=581–91 |year=2009 |last1=Watkins |first1=Linda R. |last2=Hutchinson |first2=Mark R. |last3=Rice |first3=Kenner C. |last4=Maier |first4=Steven F. }}</ref> Long-term opioid use is associated with well known dependency, addiction, and withdrawal syndromes.<ref>{{cite journal |doi=10.1007/s40263-013-0081-y |pmid=23925669 |title=Medication Overuse Headache: History, Features, Prevention and Management Strategies |journal=CNS Drugs |volume=27 |issue=11 |pages=867–77 |year=2013 |last1=Saper |first1=Joel R. |last2=Da Silva |first2=Arnaldo Neves |s2cid=39617729 }}</ref> Prescription of opioid medication may additionally lead to further delay in differential diagnosis, undertreatment, and mismanagement.<ref name=Pae2008>{{cite journal |doi=10.1007/s11916-008-0023-4 |pmid=18474192 |title=Medication-overuse headache in patients with cluster headache |journal=Current Pain and Headache Reports |volume=12 |issue=2 |pages=122–7 |year=2008 |last1=Paemeleire |first1=Koen |last2=Evers |first2=Stefan |last3=Goadsby |first3=Peter J. |s2cid=28752169 }}</ref>