Editing Exercise physiology (section)

== Selective breeding experiments with rodents ==
Rodents have been specifically bred for exercise behavior or performance in several different studies.<ref>{{Cite journal |last=Feder |first=ME |last2=Garland Jr |first2=T |last3=Marden |first3=JH |last4=Zera |first4=AJ |year=2010 |title=Locomotion in response to shifting climate zones: Not so fast |url=http://www.biology.ucr.edu/people/faculty/Garland/Feder_et_al_2010.pdf |url-status=dead |journal=Annual Review of Physiology |volume=72 |pages=167–90 |doi=10.1146/annurev-physiol-021909-135804 |pmid=20148672 |s2cid=36520695 |archive-url=https://web.archive.org/web/20231012034239/http://biology.ucr.edu/people/faculty/Garland/Feder_et_al_2010.pdf |archive-date=2023-10-12 |access-date=2011-10-31}}</ref>  For example, laboratory rats have been bred for high or low performance on a motorized treadmill with electrical stimulation as [[motivation]].<ref>{{Cite journal |last=Koch, L. G. |last2=Britton, S. L. |year=2001 |title=Artificial selection for intrinsic aerobic endurance running capacity in rats |journal=Physiological Genomics |volume=5 |issue=1 |pages=45–52 |citeseerx=10.1.1.325.7411 |doi=10.1152/physiolgenomics.2001.5.1.45 |pmid=11161005 |s2cid=2340159}}</ref> The high-performance line of rats also exhibits increased voluntary wheel-running behavior as compared with the low-capacity line.<ref>{{Cite journal |last=Waters |first=RP |last2=Renner |first2=KJ |last3=Pringle |first3=RB |last4=Summers |first4=CH |last5=Britton |first5=SL |last6=Koch |first6=LG |last7=Swallow |first7=JG |year=2008 |title=Selection for aerobic capacity affects corticosterone, monoamines and wheel-running activity |journal=Physiology & Behavior |volume=93 |issue=4–5 |pages=1044–54 |doi=10.1016/j.physbeh.2008.01.013 |pmc=2435267 |pmid=18304593}}</ref> In an [[experimental evolution]] approach, four replicate lines of laboratory mice have been bred for high levels of [[voluntary exercise]] on wheels, while four additional control lines are maintained by breeding without regard to the amount of wheel running.<ref>{{Cite journal |last=Swallow |first=JG |last2=Carter |first2=PA |last3=Garland Jr |first3=T |year=1998 |title=Artificial selection for increased wheel-running behavior in house mice |journal=Behavior Genetics |volume=28 |issue=3 |pages=227–37 |doi=10.1023/A:1021479331779 |pmid=9670598 |s2cid=18336243}}</ref> These selected lines of mice also show increased endurance capacity in tests of forced endurance capacity on a motorized treadmill.<ref>{{Cite journal |last=Meek |first=TH |last2=Lonquich |first2=BP |last3=Hannon |first3=RM |last4=Garland Jr |first4=T |year=2009 |title=Endurance capacity of mice selectively bred for high voluntary wheel running |journal=The Journal of Experimental Biology |volume=212 |issue=18 |pages=2908–17 |doi=10.1242/jeb.028886 |pmid=19717672 |doi-access=free}}</ref>  However, in neither selection experiment have the precise causes of fatigue during either forced or voluntary exercise been determined.{{cn|date=April 2025}}