Editing Non-coding RNA (section)

===miR-96 and hearing loss===

Variation within the seed region of mature [[Mir-96 microRNA|miR-96]] has been associated with [[autosomal dominant]], progressive hearing loss in humans and mice. The [[homozygous]] mutant mice were profoundly deaf, showing no [[cochlea]]r responses. [[Heterozygous]] mice and humans progressively lose the ability to hear.<ref name="pmid19363479">{{cite journal | vauthors = Mencía A, Modamio-Høybjør S, Redshaw N, Morín M, Mayo-Merino F, Olavarrieta L, Aguirre LA, del Castillo I, Steel KP, Dalmay T, Moreno F, Moreno-Pelayo MA | display-authors = 6 | title = Mutations in the seed region of human miR-96 are responsible for nonsyndromic progressive hearing loss | journal = Nature Genetics | volume = 41 | issue = 5 | pages = 609–613 | date = May 2009 | pmid = 19363479 | doi = 10.1038/ng.355 | s2cid = 11113852 }}</ref><ref name="pmid19363478">{{cite journal | vauthors = Lewis MA, Quint E, Glazier AM, Fuchs H, De Angelis MH, Langford C, van Dongen S, Abreu-Goodger C, Piipari M, Redshaw N, Dalmay T, Moreno-Pelayo MA, Enright AJ, Steel KP | display-authors = 6 | title = An ENU-induced mutation of miR-96 associated with progressive hearing loss in mice | journal = Nature Genetics | volume = 41 | issue = 5 | pages = 614–618 | date = May 2009 | pmid = 19363478 | pmc = 2705913 | doi = 10.1038/ng.369 }}</ref><ref name="pmid19245798">{{cite journal | vauthors = Soukup GA | title = Little but loud: small RNAs have a resounding affect on ear development | journal = Brain Research | volume = 1277 | pages = 104–114 | date = June 2009 | pmid = 19245798 | pmc = 2700218 | doi = 10.1016/j.brainres.2009.02.027 }}</ref>