Editing ABC transporter (section)

== Physiological role ==
In addition to conferring MDR in tumor cells, ABC transporters are also expressed in the membranes of healthy cells, where they facilitate the transport of various endogenous substances, as well as of substances foreign to the body. For instance, ABC transporters such as Pgp, the MRPs and BCRP limit the absorption of many drugs from the intestine, and pump drugs from the liver cells to the bile<ref>{{cite journal | vauthors = Annaert PP, Turncliff RZ, Booth CL, Thakker DR, Brouwer KL | date = Oct 2001 | title = P-glycoprotein-mediated in vitro biliary excretion in sandwich-cultured rat hepatocytes | journal = Drug Metab Dispos | volume = 29 | issue = 10| pages = 1277–83 | pmid = 11560870 }}</ref> as a means of removing foreign substances from the body. A large number of drugs are either transported by ABC transporters themselves or affect the transport of other drugs. The latter scenario can lead to [[Drug interaction|drug-drug interactions]],<ref name="ReferenceA">{{cite journal | vauthors = Annaert PP, Brouwer KL | date = Mar 2005 | title = Assessment of drug interactions in hepatobiliary transport using rhodamine 123 in sandwich-cultured rat hepatocytes | journal = Drug Metab Dispos | volume = 33 | issue = 3| pages = 388–94 | doi = 10.1124/dmd.104.001669 | pmid = 15608134 | s2cid = 7063502 }}</ref> sometimes resulting in altered effects of the drugs.<ref>{{Cite journal | url=http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8371 | title=ATP-Binding Cassette Efflux Transporters and Passive Membrane Permeability in Drug Absorption and Disposition| journal=Diva| year=2007| last1=Matsson| first1=Pär}}</ref>