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Aggression
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===Pheromones=== In many animals, aggression can be linked to [[pheromone]]s released between [[conspecifics]]. In mice, [[major urinary proteins]] (Mups) have been demonstrated to promote innate aggressive behavior in males,<ref name="BBCreport">{{cite news |title=Aggression protein found in mice |work=[[BBC News]] |date=5 December 2007 |url=http://news.bbc.co.uk/2/hi/science/nature/7129176.stm |access-date=26 September 2009}}</ref><ref name=Chamero1>{{cite journal |author=Chamero P |title=Identification of protein pheromones that promote aggressive behaviour |journal=Nature |volume=450 |issue=7171 |pages=899β902 |date=December 2007 |pmid=18064011 |doi=10.1038/nature05997 |author2=Marton TF |author3=Logan DW |display-authors=3 |last4=Flanagan |first4=Kelly |last5=Cruz |first5=Jason R. |last6=Saghatelian |first6=Alan |last7=Cravatt |first7=Benjamin F. |last8=Stowers |first8=Lisa|bibcode=2007Natur.450..899C |s2cid=4398766 }}</ref> and can be mediated by neuromodulatory systems.<ref>{{cite journal |doi=10.1523/JNEUROSCI.0099-15.2015 |pmid=26224860 |pmc=4518052 |title=Differential Muscarinic Modulation in the Olfactory Bulb |journal=Journal of Neuroscience |volume=35 |issue=30 |pages=10773β85 |year=2015 |last1=Smith |first1=R. S. |last2=Hu |first2=R. |last3=Desouza |first3=A. |last4=Eberly |first4=C. L. |last5=Krahe |first5=K. |last6=Chan |first6=W. |last7=Araneda |first7=R. C. }}</ref> Mups activate [[olfactory sensory neuron]]s in the [[vomeronasal organ]] (VNO), a subsystem of the nose known to detect pheromones via specific [[sensory receptor]]s, of mice<ref name=Chamero1/> and rats.<ref name=Krieger1>{{cite journal |doi=10.1074/jbc.274.8.4655 |pmid=9988702 |title=Selective Activation of G Protein Subtypes in the Vomeronasal Organ upon Stimulation with Urine-derived Compounds |journal=Journal of Biological Chemistry |volume=274 |issue=8 |pages=4655β62 |year=1999 |last1=Krieger |first1=J. |last2=Schmitt |first2=A. |last3=Lobel |first3=D. |last4=Gudermann |first4=T. |last5=Schultz |first5=G. |last6=Breer |first6=H. |last7=Boekhoff |first7=I. |doi-access=free }}</ref> Pheremones have also been identified in [[Drosophila melanogaster|fruit flies]], detected by neurons in the antenna, that send a message to the brain eliciting aggression; it has been noted that aggression pheremones have not been identified in humans.<ref>[https://web.archive.org/web/20091209075216/http://media.caltech.edu/press_releases/13308 Caltech Scientists Discover Aggression-Promoting Pheromone in Flies] Caltech press release, 2009</ref>
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