Editing Bioinformatics (section)

===Nuclear organization of chromatin===
{{main|Nuclear organization}}
Data from high-throughput [[chromosome conformation capture]] experiments, such as [[Hi-C (experiment)]] and [[ChIA-PET]], can provide information on the three-dimensional structure and [[nuclear organization]] of [[chromatin]]. Bioinformatic challenges in this field include partitioning the genome into domains, such as [[Topologically Associating Domain]]s (TADs), that are organised together in three-dimensional space.<ref>{{cite journal | vauthors = Ay F, Noble WS | title = Analysis methods for studying the 3D architecture of the genome | journal = Genome Biology | volume = 16 | issue = 1 | pages = 183 | date = September 2015 | pmid = 26328929 | pmc = 4556012 | doi = 10.1186/s13059-015-0745-7 | doi-access = free }}</ref>