Editing Cachexia (section)

===Medications===
Some medications, such as [[glucocorticoid]]s, [[cannabinoid]]s, and [[progestin]]s were initially used in treating cachexia and aim to increase appetite.<ref name="setiawan-2023" /> Progestins showed promise initially, but they do not stop muscle wasting and may cause fluid retention, fat gain, and other side effects.<ref name="sadeghi-2018" /><ref name="peterson-2017" /><ref name="setiawan-2023" /><ref name="epcrc-2010" />

Ghrelin agonists, such as [[Anamorelin]] are commonly used in cancer treatment to boost appetite, increase weight, and increase muscle mass.<ref name="setiawan-2023" /> However, its use and effectiveness in cachexia is not well studied.

Selective androgen receptor modulators (SARMs) such as Enobosarm show promise in increasing physical performance and muscle mass, but more studies are needed to confirm their effectiveness in cachexia.<ref name="sadeghi-2018" />

The use of anti-inflammatory medications have been investigated. [[Thalidomide]], an anti-inflammatory agent, has shown promise in preventing weight loss, but the use of this medication in cachexia is not widely accepted.<ref name="sadeghi-2018" /><ref>{{cite journal |vauthors=Reid J, Mills M, Cantwell M, Cardwell CR, Murray LJ, Donnelly M |date=April 2012 |title=Thalidomide for managing cancer cachexia |journal=The Cochrane Database of Systematic Reviews |volume=2021 |issue=4 |pages=CD008664 |doi=10.1002/14651858.cd008664.pub2 |pmc=6353113 |pmid=22513961}}</ref> However, other TNF inhibitors have not shown the same promising results.<ref name="setiawan-2023" /> [[Nonsteroidal anti-inflammatory drug|NSAIDs]] such as celecoxib and ibuprofen showed some early benefits, but side effects (renal injury, GI bleeding) limit their use.<ref name="sadeghi-2018" />

Anti-nausea drugs such as [[5-HT3 antagonist|5-HT<sub>3</sub> antagonists]] are also commonly used if nausea is a prominent symptom.<ref name="Kumar" />

[[Anabolic-androgenic steroid|Anabolic steroid]]s like [[oxandrolone]] may help but are only recommended for short term use due to [[side effect]]s including liver toxicity.<ref name="sadeghi-2018" /><ref name="epcrc-2010" /><ref name="Mantovani2007">{{cite book |author=Giovanni Mantovani |url=https://books.google.com/books?id=lQyGxrmQ17AC&pg=PA673 |title=Cachexia and Wasting: A Modern Approach |date=6 October 2007 |publisher=Springer Science & Business Media |isbn=978-88-470-0552-5 |pages=673–}}</ref>