Editing Clostridium perfringens (section)

=== Other toxins ===
TpeL is a toxin found in type B, C, and G<ref name="pmid340765062">{{cite journal |last1=Orrell |first1=KE |last2=Melnyk |first2=RA |date=18 August 2021 |title=Large Clostridial Toxins: Mechanisms and Roles in Disease. |journal=Microbiology and Molecular Biology Reviews |volume=85 |issue=3 |pages=e0006421 |doi=10.1128/MMBR.00064-21 |pmc=8483668 |pmid=34076506}}</ref> strains. It is in the same [[protein family]] as [[Clostridium difficile toxin A|''C. difficile'' toxin A]].<ref>{{cite journal |last1=Chen |first1=J |last2=McClane |first2=BA |date=June 2015 |title=Characterization of Clostridium perfringens TpeL toxin gene carriage, production, cytotoxic contributions, and trypsin sensitivity. |journal=Infection and Immunity |volume=83 |issue=6 |pages=2369–81 |doi=10.1128/IAI.03136-14 |pmc=4432761 |pmid=25824828}}</ref> It does not appear important in the pathogenesis of types B and C infections, but may contribute to virulence in type G strains. It glycosylates Rho and [[Ras GTPase]]s, disrupting host cell signaling.<ref name="pmid340765062" />