Editing Comparative genomic hybridization (section)

====Prenatal genetic diagnosis====
Though not yet a widely employed technique, the use of array CGH as a tool for preimplantation genetic screening is becoming an increasingly popular concept. It has the potential to detect CNVs and [[aneuploidy]] in eggs, sperm or embryos which may contribute to failure of the embryo to successfully implant, miscarriage or conditions such as Down syndrome (trisomy 21). This makes array CGH a promising tool to reduce the incidence of life altering conditions and improve success rates of [[IVF]] attempts. The technique involves whole genome amplification from a single cell which is then used in the array CGH method. It may also be used in couples carrying [[chromosome translocations|chromosomal translocations]] such as balanced reciprocal translocations or Robertsonian translocations, which have the potential to cause chromosomal imbalances in their offspring.<ref name="Evangelidou,Alexandrou,Moutafi,Ioannides,Antonios,Koumbaris,Kallikas,Velissariou,Sismani,Patsalis" /><ref>{{cite journal | vauthors = Fiorentino F | s2cid = 6484211 | year = 2012 | title = Array comparative genomic hybridization: its role in preimplantation genetic diagnosis | journal = Current Opinion in Obstetrics and Gynecology | volume = 24 | issue = 4| pages = 203–209 | doi=10.1097/gco.0b013e328355854d| pmid = 22729095 }}</ref><ref>{{cite journal | vauthors = Lee CN, Lin SY, Lin CH, Shih JC, Lin TH, Su YN|author-link4=Jean Chen Shih | year = 2012 | title = Clinical utility of array comparative genomic hybridization for prenatal diagnosis: a cohort study of 3171 pregnancies | journal = BJOG: An International Journal of Obstetrics & Gynaecology | volume = 119 | issue = 5| pages = 614–625 | doi=10.1111/j.1471-0528.2012.03279.x|pmid=22313859 | doi-access = free }}</ref>