Editing AMPA receptor (section)

=== AMPAR Trafficking Deficits in Schizophrenia and Autism ===

==== Schizophrenia ====
Abnormal [[N-linked glycosylation]] of AMPAR subunits has been reported in schizophrenia, suggesting impaired receptor trafficking and synaptic localization, which may underlie [[glutamatergic]] dysfunction observed in the disorder.<ref>{{Cite journal |last1=Tucholski |first1=Janusz |last2=Simmons |first2=Micah S. |last3=Pinner |first3=Anita L. |last4=Haroutunian |first4=Vahram |last5=McCullumsmith |first5=Robert E. |last6=Meador-Woodruff |first6=James H. |date=May 2013 |title=Abnormal N-linked glycosylation of cortical AMPA receptor subunits in schizophrenia |journal=Schizophrenia Research |language=en |volume=146 |issue=1–3 |pages=177–183 |doi=10.1016/j.schres.2013.01.031 |pmc=3655690 |pmid=23462048}}</ref>

==== Autism Spectrum Disorders (ASD) ====
Alterations in AMPAR trafficking have been implicated in ASD.  Studies indicate that dysregulation of proteins involved in AMPAR trafficking, such as [[CYFIP1]], leads to synaptic dysfunction associated with autism-like behaviors.<ref>{{Cite journal |last1=Pathania |first1=M |last2=Davenport |first2=E C |last3=Muir |first3=J |last4=Sheehan |first4=D F |last5=López-Doménech |first5=G |last6=Kittler |first6=J T |date=2014-03-25 |title=The autism and schizophrenia associated gene CYFIP1 is critical for the maintenance of dendritic complexity and the stabilization of mature spines |journal=Translational Psychiatry |language=en |volume=4 |issue=3 |pages=e374 |doi=10.1038/tp.2014.16 |issn=2158-3188 |pmc=3966042 |pmid=24667445}}</ref>