Editing Candida albicans (section)

===Filamentation===
The ability to switch between yeast cells and hyphal cells is an important virulence factor. Many proteins play a role in this  very complex process.<ref>{{cite journal | vauthors = Azadmanesh J, Gowen AM, Creger PE, Schafer ND, Blankenship JR | title = Filamentation Involves Two Overlapping, but Distinct, Programs of Filamentation in the Pathogenic Fungus ''Candida albicans'' | journal = G3 | volume = 7 | issue = 11 | pages = 3797–3808 | date = November 2017 | pmid = 28951491 | pmc = 5677161 | doi = 10.1534/g3.117.300224 }}</ref> The formation of hyphae can for example help ''Candida albicans'' to escape from macrophages in the human body.<ref>{{cite journal | vauthors = Lorenz MC, Bender JA, Fink GR | title = Transcriptional response of Candida albicans upon internalization by macrophages | journal = Eukaryotic Cell | volume = 3 | issue = 5 | pages = 1076–1087 | date = October 2004 | pmid = 15470236 | pmc = 522606 | doi = 10.1128/EC.3.5.1076-1087.2004 }}</ref> Moreover, ''C. albicans'' undergo yeast-to-hyphal transition within the acidic macrophage phagosome. This initially causes phagosome membrane distension which eventually leads to phagosomal alkalinization by physical rupture, followed by escape.<ref>{{cite journal | vauthors = Westman J, Moran G, Mogavero S, Hube B, Grinstein S | title = Candida albicans Hyphal Expansion Causes Phagosomal Membrane Damage and Luminal Alkalinization | journal = mBio | volume = 9 | issue = 5 | pages = e01226–18 | date = September 2018 | pmid = 30206168 | pmc = 6134096 | doi = 10.1128/mBio.01226-18 }}</ref>