Editing Delayed puberty (section)

=== Others ===
[[Growth hormone]] is another option that has been described, however it should only be used in proven growth hormone deficiency<ref>{{cite journal | vauthors = Heinrichs C, Bourguignon JP | title = Treatment of delayed puberty and hypogonadism in girls | journal = Hormone Research | volume = 36 | issue = 3–4 | pages = 147–52 | year = 1991 | pmid = 1818011 | doi = 10.1159/000182149 | hdl = 2268/260267 | hdl-access = free }}</ref><ref name="pmid12970282">{{cite journal | vauthors = Massa G, Heinrichs C, Verlinde S, Thomas M, Bourguignon JP, Craen M, François I, Du Caju M, Maes M, De Schepper J | title = Late or delayed induced or spontaneous puberty in girls with Turner syndrome treated with growth hormone does not affect final height | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 88 | issue = 9 | pages = 4168–74 | date = September 2003 | pmid = 12970282 | doi = 10.1210/jc.2002-022040 | hdl = 2268/257143 | hdl-access = free }}</ref> such as [[idiopathic short stature]].<ref name=":7" /> Children with a constitutional delay have not been shown to benefit from growth hormone therapy.<ref name=":7" /> Although serum growth hormone levels are low in constitutional delay of puberty, they increase after treatment with sex hormones and in those cases, growth hormone is not suggested to accelerate growth.<ref name=":0" />

Subnormal [[vitamin A]] intake is one of the etiological factors in delayed pubertal maturation. Supplementation of both vitamin A and [[iron]] to normal constitutionally delayed children with subnormal vitamin A intake is as efficacious as hormonal therapy in the induction of growth and puberty.<ref>{{cite journal | vauthors = Zadik Z, Sinai T, Zung A, Reifen R | title = Vitamin A and iron supplementation is as efficient as hormonal therapy in constitutionally delayed children | journal = Clinical Endocrinology | volume = 60 | issue = 6 | pages = 682–7 | date = June 2004 | pmid = 15163330 | doi = 10.1111/j.1365-2265.2004.02034.x | s2cid = 27016335 }}</ref>

More therapies are being developed to target the more discreet modulators of the [[HPG axis]] including [[kisspeptin]] and [[neurokinin B]].<ref>{{cite book | vauthors = Newton CL, Anderson RC, Millar RP | title = Advanced Therapies in Pediatric Endocrinology and Diabetology | chapter = Therapeutic Neuroendocrine Agonist and Antagonist Analogs of Hypothalamic Neuropeptides as Modulators of the Hypothalamic-Pituitary-Gonadal Axis | language = en | journal = Endocrine Development | volume = 30 | pages = 106–29 | date = 2016 | pmid = 26684214 | doi = 10.1159/000439337 | isbn = 978-3-318-05636-5 }}</ref><ref>{{cite journal | vauthors = Wei C, Crowne EC | title = Recent advances in the understanding and management of delayed puberty | journal = Archives of Disease in Childhood | volume = 101 | issue = 5 | pages = 481–8 | date = May 2016 | pmid = 26353794 | doi = 10.1136/archdischild-2014-307963 | s2cid = 5372175 }}</ref>

In cases of severe delayed puberty secondary to [[hypogonadism]], evaluation by a psychologist or psychiatrist, as well as counseling and a supportive environment are an important supplemental therapy for the child.<ref name=":1" /><ref name="pmid25735941">{{cite book | vauthors = Berenbaum SA, Beltz AM, Corley R | title = The importance of puberty for adolescent development: conceptualization and measurement | journal = Advances in Child Development and Behavior | volume = 48 | pages = 53–92 | date = 2015 | pmid = 25735941 | doi = 10.1016/bs.acdb.2014.11.002 | isbn = 9780128021781 }}</ref> Transition from pediatric to adult care is also vital as many children are lost during transition of care.<ref name=":8" />