Editing Infective endocarditis (section)

==Epidemiology==
In [[developed country|developed countries]], the annual [[incidence (epidemiology)|incidence]] of infective endocarditis is 3 to 9 cases per 100,000 persons.<ref name="NEJM Review, Hoen">{{cite journal | vauthors = Hoen B, Duval X | title = Clinical practice. Infective endocarditis | journal = The New England Journal of Medicine | volume = 368 | issue = 15 | pages = 1425–33 | date = April 2013 | pmid = 23574121 | doi = 10.1056/NEJMcp1206782 }}</ref> Infective endocarditis occurs more often in men than in women.<ref name="Hubers2020"/> There is an increased incidence of infective endocarditis in persons 65 years of age and older, which is probably because people in this age group have a larger number of risk factors for infective endocarditis. In recent years, over one-third of infective endocarditis cases in the United States was [[Iatrogenesis|healthcare-associated]].<ref name="NEJM Review, Hoen" /> Another trend observed in developed countries is that chronic [[Rheumatic fever#Rheumatic heart disease|rheumatic heart disease]] accounts for less than 10% of cases. Although a history of valve disease has a significant association with infective endocarditis, 50% of all cases develop in people with no known history of valvular disease.{{citation needed|date=February 2021}}