Editing Multiple sclerosis (section)

===McDonald criteria===
The [[McDonald criteria]], which focus on clinical, laboratory, and radiologic evidence of lesions at different times and in different areas, is the most commonly used method of diagnosis<ref name=Atlas2008>{{cite book |author=World Health Organization |title=Atlas: Multiple Sclerosis Resources in the World 2008 |publisher=World Health Organization |location=Geneva |year=2008 |pages=15–16 |isbn=978-92-4-156375-8 |hdl=10665/43968 |hdl-access=free }}</ref> with the [[Schumacher criteria|Schumacher]] and [[Poser criteria]] being of mostly historical significance.<ref name="pmid15177763">{{cite journal | vauthors = Poser CM, Brinar VV | title = Diagnostic criteria for multiple sclerosis: an historical review | journal = Clinical Neurology and Neurosurgery | volume = 106 | issue = 3 | pages = 147–58 | date = June 2004 | pmid = 15177763 | doi = 10.1016/j.clineuro.2004.02.004 | s2cid = 23452341 }}</ref> The McDonald criteria states that patients with multiple sclerosis should have lesions which are disseminated in time (DIT) and disseminated in space (DIS), i.e. lesions which have appeared in different areas in the brain and at different times.<ref name="Thompson-2018"/> Below is an abbreviated outline of the 2017 McDonald Criteria for diagnosis of MS.
* At least 2 clinical attacks with MRI showing 2 or more lesions characteristic of MS.<ref name="Thompson-2018" />
* At least 2 clinical attacks with MRI showing 1 lesion characteristic of MS with clear historical evidence of a previous attack involving a lesion at a distinct location in the CNS.<ref name="Thompson-2018" />
* At least 2 clinical attacks with MRI showing 1 lesion characteristic of MS, with DIT established by an additional clinical attack at a distinct CNS site or by MRI showing an old MS lesion.<ref name="Thompson-2018" />
* 1 clinical attack with MRI showing at least 2 lesions characteristic of MS, with DIT established by an additional attack, by MRI showing old MS lesion(s), or presence of oligoclonal bands in CSF.<ref name="Thompson-2018" />
* 1 clinical attack with MRI showing 1 lesion characteristic of MS, with DIS established by an additional attack at a different CNS site or by MRI showing old MS lesion(s), and DIT established by an additional attack, by MRI showing old MS lesion(s), or presence of oligoclonal bands in CSF.<ref name="Thompson-2018" />

{{as of|2017}}, no single test (including biopsy) can provide a definitive diagnosis.<ref>{{cite journal | vauthors = Rovira À | title = Diagnosis of Multiple Sclerosis| journal = Journal of the Belgian Society of Radiology | volume = 101 | issue = S1 | pages = 12 | date = November 2017 | doi = 10.5334/jbr-btr.1426| doi-access = free }}</ref>