Editing Partition coefficient (section)

===Fragment-based===
The most common of these uses a [[group contribution method]] and is termed cLogP. It has been shown that the log ''P'' of a compound can be determined by the sum of its non-overlapping molecular fragments (defined as one or more atoms covalently bound to each other within the molecule). Fragmentary log ''P'' values have been determined in a statistical method analogous to the atomic methods (least-squares fitting to a training set). In addition, [[Hammett equation|Hammett-type corrections]] are included to account of [[Inductive effect|electronic]] and [[steric effects]]. This method in general gives better results than atomic-based methods, but cannot be used to predict partition coefficients for molecules containing unusual functional groups for which the method has not yet been parameterized (most likely because of the lack of experimental data for molecules containing such functional groups).<ref name="Hansch"/>{{rp|125ff}}<ref name="Leo2"/>{{rp|1–193}}