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Peripheral neuropathy
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==Research== A 2008 literature review concluded that "based on principles of [[evidence-based medicine]] and evaluations of methodology, there is only a 'possible' association of [[celiac disease]] and peripheral neuropathy due to lower levels of evidence and conflicting evidence. There is not yet convincing evidence of causality."<ref name="pmid18344378">{{cite journal | vauthors = Grossman G | title = Neurological complications of coeliac disease: what is the evidence? | journal = Practical Neurology | volume = 8 | issue = 2 | pages = 77β89 | date = April 2008 | pmid = 18344378 | doi = 10.1136/jnnp.2007.139717 | s2cid = 28327166 }}</ref> A 2019 review concluded that "gluten neuropathy is a slowly progressive condition. About 25% of the patients will have evidence of enteropathy on biopsy (CD [celiac disease]) but the presence or absence of an enteropathy does not influence the positive effect of a strict gluten-free diet."<ref name=ZisHadjivassiliou2019>{{cite journal | vauthors = Zis P, Hadjivassiliou M | title = Treatment of Neurological Manifestations of Gluten Sensitivity and Coeliac Disease | journal = Current Treatment Options in Neurology | volume = 21 | issue = 3 | pages = 10 | date = February 2019 | pmid = 30806821 | doi = 10.1007/s11940-019-0552-7 | s2cid = 73466457 | type = Review | doi-access = free }}</ref> [[Stem-cell therapy]] is also being examined as a possible means to repair peripheral nerve damage but efficacy has not yet been demonstrated.<ref>{{cite journal | vauthors = Sayad Fathi S, Zaminy A | title = Stem cell therapy for nerve injury | journal = World Journal of Stem Cells | volume = 9 | issue = 9 | pages = 144β151 | date = September 2017 | pmid = 29026460 | pmc = 5620423 | doi = 10.4252/wjsc.v9.i9.144 | doi-access = free }}</ref><ref>{{cite journal | vauthors = Xu W, Cox CS, Li Y | title = Induced pluripotent stem cells for peripheral nerve regeneration | journal = Journal of Stem Cells | volume = 6 | issue = 1 | pages = 39β49 | pmid = 22997844 | year = 2011 }}</ref><ref>{{cite journal | vauthors = Zhou JY, Zhang Z, Qian GS | title = Mesenchymal stem cells to treat diabetic neuropathy: a long and strenuous way from bench to the clinic | journal = Cell Death Discovery | volume = 2 | pages = 16055 | pmid = 27551543 | pmc = 4979500 | doi = 10.1038/cddiscovery.2016.55 | year = 2016 }}</ref>
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