Editing Angiogenesis (section)

===Tissue engineered constructs===
Angiogenesis of vessels from the host body into an implanted tissue engineered constructs is essential. Successful integration is often dependent on thorough vascularisation of the construct as it provides oxygen and nutrients and prevents necrosis in the central  areas  of  the  implant.<ref>{{cite journal | vauthors = Rouwkema J, Khademhosseini A | title = Vascularization and Angiogenesis in Tissue Engineering: Beyond Creating Static Networks | journal = Trends in Biotechnology | volume = 34 | issue = 9 | pages = 733–745 | date = September 2016 | pmid = 27032730 | doi = 10.1016/j.tibtech.2016.03.002 | url = https://research.utwente.nl/en/publications/f67df178-6066-4fe2-afb3-58a570fe4b78 }}</ref>  PDGF has been shown to stabilize vascularisation in collagen-[[glycosaminoglycan]] scaffolds.<ref>{{cite journal | vauthors = do Amaral RJ, Cavanagh B, O'Brien FJ, Kearney CJ | title = Platelet-derived growth factor stabilises vascularisation in collagen-glycosaminoglycan scaffolds in vitro | journal = Journal of Tissue Engineering and Regenerative Medicine | volume = 13 | issue = 2 | pages = 261–273 | date = February 2019 | pmid = 30554484 | doi = 10.1002/term.2789 | s2cid = 58767660 | doi-access = free }}</ref>