Editing Caudate nucleus (section)

===Obsessive-compulsive disorder===
It has been theorized that the caudate nucleus may be dysfunctional in persons with [[obsessive compulsive disorder]] (OCD), in that it may perhaps be unable to properly regulate the transmission of information regarding worrying events or ideas between the [[thalamus]] and the [[orbitofrontal cortex]].

A [[neuroimaging]] study with [[positron emission tomography]] found that the right caudate nucleus had the largest change in glucose metabolism after patients had been treated with [[paroxetine]].<ref>{{cite journal | vauthors = Hansen ES, Hasselbalch S, Law I, Bolwig TG | title = The caudate nucleus in obsessive-compulsive disorder. Reduced metabolism following treatment with paroxetine: a PET study | journal = The International Journal of Neuropsychopharmacology | volume = 5 | issue = 1 | pages = 1–10 | date = March 2002 | pmid = 12057027 | doi = 10.1017/S1461145701002681 | doi-access = free }}</ref>  Recent [[Seed-based d mapping|SDM meta-analyses]] of [[voxel-based morphometry]] studies comparing people with OCD and healthy controls have found people with OCD to have increased [[grey matter]] volumes in bilateral [[lenticular nucleus|lenticular nuclei]], extending to the caudate nuclei, while decreased grey matter volumes in bilateral dorsal [[medial frontal gyrus|medial frontal]]/[[anterior cingulate cortex|anterior cingulate]] gyri.<ref name="Radua and Mataix-Cols, 2009">{{cite journal | vauthors = Radua J, Mataix-Cols D | title = Voxel-wise meta-analysis of grey matter changes in obsessive-compulsive disorder | journal = The British Journal of Psychiatry | volume = 195 | issue = 5 | pages = 393–402 | date = November 2009 | pmid = 19880927 | doi = 10.1192/bjp.bp.108.055046 | doi-access = free }}</ref><ref name=radua2010>{{cite journal | vauthors = Radua J, van den Heuvel OA, Surguladze S, Mataix-Cols D | title = Meta-analytical comparison of voxel-based morphometry studies in obsessive-compulsive disorder vs other anxiety disorders | journal = Archives of General Psychiatry | volume = 67 | issue = 7 | pages = 701–11 | date = July 2010 | pmid = 20603451 | doi = 10.1001/archgenpsychiatry.2010.70 | doi-access = free }}
</ref> These findings contrast with those in people with other anxiety disorders, who evince decreased (rather than increased) [[grey matter]] volumes in bilateral [[lenticular nucleus|lenticular]] / caudate nuclei, while also decreased grey matter volumes in bilateral dorsal [[medial frontal gyrus|medial frontal]]/[[anterior cingulate cortex|anterior cingulate]] gyri.<ref name=radua2010 />