Editing Coagulation (section)

===Platelet disorders===
Platelet disorders are either congenital or acquired. Examples of congenital platelet disorders are [[Glanzmann's thrombasthenia]], [[Bernard–Soulier syndrome]] (abnormal [[Glycoprotein Ib-IX-V Receptor Complex|glycoprotein Ib-IX-V complex]]), [[gray platelet syndrome]] (deficient [[alpha granules]]), and [[delta storage pool deficiency]] (deficient [[dense granules]]). Most are rare. They predispose to hemorrhage. [[Von Willebrand disease]] is due to deficiency or abnormal function of [[von Willebrand factor]], and leads to a similar bleeding pattern; its milder forms are relatively common.{{Citation needed|date=November 2021}}

Decreased platelet numbers (thrombocytopenia) is due to insufficient production (e.g., [[myelodysplastic syndrome]] or other bone marrow disorders), destruction by the immune system ([[immune thrombocytopenic purpura]]), or consumption (e.g., [[thrombotic thrombocytopenic purpura]], [[hemolytic-uremic syndrome]], [[paroxysmal nocturnal hemoglobinuria]], [[disseminated intravascular coagulation]], [[heparin-induced thrombocytopenia]]).<ref>{{Cite web |title=Disseminated Intravascular Coagulation |url=https://www.lecturio.com/concepts/disseminated-intravascular-coagulation/ |url-status=live |archive-url=https://web.archive.org/web/20210712111249/https://www.lecturio.com/concepts/disseminated-intravascular-coagulation/ |archive-date=12 July 2021 |access-date=12 July 2021 |website=The Lecturio Medical Concept Library}}</ref> An increase in platelet count is called [[thrombocytosis]], which may lead to formation of [[Thrombosis|thromboembolisms]]; however, thrombocytosis may be associated with increased risk of either thrombosis or hemorrhage in patients with [[myeloproliferative neoplasm]].<ref>{{Cite journal |vauthors=Andreescu M, Andreescu B |date=March 2024 |title=A Review About the Assessment of the Bleeding and Thrombosis Risk for Patients With Myeloproliferative Neoplasms Scheduled for Surgery |journal=Cureus |volume=16 |issue=3 |page=e56008 |doi=10.7759/cureus.56008 |pmc=11007487 |pmid=38606222 |doi-access=free}}</ref>