Editing Delayed puberty (section)

== Outlook ==
Constitutional delay of growth and puberty is a variation of normal development with no long-term health consequences, however it can have lasting psychological effects.<ref name=":02" /><ref>{{Cite book|title=Endocrinology adult and pediatric : reproductive endocrinology| first1 = J. Larry | last1 = Jameson | first2 = David | last2 = de Kretser | first3 = John C. | last3 = Marshall | name-list-style = vanc |isbn=9780323240604 |edition=6th |location=Philadelphia |oclc=881479176 |year = 2013}}</ref> Adolescent boys with delayed puberty have a higher level of anxiety and depression relative to their peers.<ref name=":82">{{cite journal | vauthors = Dwyer AA, Phan-Hug F, Hauschild M, Elowe-Gruau E, Pitteloud N | title = TRANSITION IN ENDOCRINOLOGY: Hypogonadism in adolescence | journal = European Journal of Endocrinology | volume = 173 | issue = 1 | pages = R15–24 | date = July 2015 | pmid = 25653257 | doi = 10.1530/EJE-14-0947 | doi-access = free }}</ref> Children with delayed puberty also display decreased academic performance in their adolescent education, but changes in academic achievement in adulthood have not been determined.<ref name=":02" />

There is conflicting evidence as to whether or not children with constitutional growth and pubertal delay reach their full height potential.<ref name=":02" /> The conventional teaching is that these children catch up on their growth during the pubertal growth spurt and just remain shorter before their delayed puberty starts.<ref>{{cite journal | vauthors = Prader A | title = Delayed adolescence | journal = Clinics in Endocrinology and Metabolism | volume = 4 | issue = 1 | pages = 143–55 | date = March 1975 | pmid = 166776 | doi = 10.1016/S0300-595X(75)80037-5 }}</ref> However, some studies show that these children fall short of their target height from about 4 to 11&nbsp;cm.<ref name=":02" /> Factors that could affect final height include familial short stature and pre-pubertal growth development.<ref name=":02" />

Pubertal delay can also affect bone mass and subsequent development of osteoporosis.<ref>{{cite journal | author = NIH Consensus Development Panel on Osteoporosis Prevention Diagnosis and Therapy | title = Osteoporosis prevention, diagnosis, and therapy | journal = JAMA | volume = 285 | issue = 6 | pages = 785–95 | date = February 2001 | pmid = 11176917 | doi = 10.1001/jama.285.6.785 }}</ref> Men with delayed puberty often have low to normal [[bone mineral density]] unaffected by [[androgen]] therapy.<ref name=":02" /> Women are more likely to have lower bone mineral density and thus an increased risk of fractures as early as even before the onset of puberty.<ref name=":02" />

Furthermore, delayed puberty is correlated with a higher risk in cardiovascular and metabolic disorders in women only, but also appears to be protective for breast and endometrial in women and testicular cancer in men.<ref name=":02" />