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Infective endocarditis
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==History== {{Blockquote |text=Few diseases present greater difficulties in the way of diagnosis than malignant endocarditis, difficulties which in many cases are practically insurmountable. It is no disparagement to the many skilled physicians who have put their cases upon record to say that, in fully one-half the diagnosis was made post mortem. |author= William Osler, 1885 }} [[Lazare Riviére]] first described infective endocarditis affecting the [[aortic valve]] in 1616.<ref name="Hubers2020"/> In 1806, [[Jean-Nicolas Corvisart]] coined the term ''vegetation'' to describe collections of debris found on a mitral valve affected by infective endocarditis.<ref name="Hubers2020"/> The British [[physician]] [[Joseph Hodgson]] was the first to describe the embolic complications of infective endocarditis in 1815.<ref name="Hubers2020"/> It was not until 1878 that [[Theodor Klebs]] first suggested that infective endocarditis had a microbial infectious origin.<ref name="Hubers2020"/> In 1909, [[William Osler]] noted that heart valves that experienced degeneration and were sclerotic or poorly functioning had a higher risk of being affected.<ref name="Hubers2020"/> Later, in 1924, [[Emanuel Libman]] and Benjamin Sacks described cases of [[Libman-Sacks endocarditis|vegetative endocarditis]] that lacked a clear microbial origin and were often associated with the autoimmune condition [[systemic lupus erythematosus]].<ref name="Hubers2020"/> In 1944, physicians reported on the first successful use of [[penicillin]] to treat a case of infective endocarditis.<ref name="Hubers2020"/>
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