Editing Notch signaling pathway (section)

=== Pancreatic development ===

The formation of the pancreas from endoderm begins in early development. The expression of elements of the Notch signaling pathway have been found in the developing pancreas, suggesting that Notch signaling is important in pancreatic development.<ref name="pmid10476967">{{cite journal | vauthors = Apelqvist A, Li H, Sommer L, Beatus P, Anderson DJ, Honjo T, Hrabe de Angelis M, Lendahl U, Edlund H | display-authors = 6 | title = Notch signalling controls pancreatic cell differentiation | journal = Nature | volume = 400 | issue = 6747 | pages = 877–881 | date = August 1999 | pmid = 10476967 | doi = 10.1038/23716 | s2cid = 4338027 | bibcode = 1999Natur.400..877A }}</ref><ref name="pmid10842072">{{cite journal | vauthors = Lammert E, Brown J, Melton DA | title = Notch gene expression during pancreatic organogenesis | journal = Mechanisms of Development | volume = 94 | issue = 1–2 | pages = 199–203 | date = June 2000 | pmid = 10842072 | doi = 10.1016/S0925-4773(00)00317-8 | s2cid = 9931966 | doi-access =  }}</ref> Evidence suggests Notch signaling regulates the progressive recruitment of endocrine cell types from a common precursor,<ref name="pmid12941629">{{cite journal | vauthors = Field HA, Dong PD, Beis D, Stainier DY | title = Formation of the digestive system in zebrafish. II. Pancreas morphogenesis | journal = Developmental Biology | volume = 261 | issue = 1 | pages = 197–208 | date = September 2003 | pmid = 12941629 | doi = 10.1016/S0012-1606(03)00308-7 | doi-access =  }}</ref> acting through two possible mechanisms. One is the "lateral inhibition", which specifies some cells for a primary fate but others for a secondary fate among cells that have the potential to adopt the same fate. Lateral inhibition is required for many types of cell fate determination. Here, it could explain the dispersed distribution of endocrine cells within pancreatic epithelium.<ref name="pmid10615124">{{cite journal | vauthors = Jensen J, Pedersen EE, Galante P, Hald J, Heller RS, Ishibashi M, Kageyama R, Guillemot F, Serup P, Madsen OD | display-authors = 6 | title = Control of endodermal endocrine development by Hes-1 | journal = Nature Genetics | volume = 24 | issue = 1 | pages = 36–44 | date = January 2000 | pmid = 10615124 | doi = 10.1038/71657 | s2cid = 52872659 }}</ref> A second mechanism is "suppressive maintenance", which explains the role of Notch signaling in pancreas differentiation. Fibroblast growth factor10 is thought to be important in this activity, but the details are unclear.<ref name="pmid14699589">{{cite journal | vauthors = Jensen J | title = Gene regulatory factors in pancreatic development | journal = Developmental Dynamics | volume = 229 | issue = 1 | pages = 176–200 | date = January 2004 | pmid = 14699589 | doi = 10.1002/dvdy.10460 | doi-access = free }}</ref><ref name="pmid14651921">{{cite journal | vauthors = Norgaard GA, Jensen JN, Jensen J | title = FGF10 signaling maintains the pancreatic progenitor cell state revealing a novel role of Notch in organ development | journal = Developmental Biology | volume = 264 | issue = 2 | pages = 323–338 | date = December 2003 | pmid = 14651921 | doi = 10.1016/j.ydbio.2003.08.013 | title-link = Pancreatic Progenitor Cell | doi-access = free }}</ref>