Editing Plasmodium falciparum (section)

=== Uncomplicated malaria ===
According to WHO guidelines 2010,<ref name=who2010>[https://web.archive.org/web/20100310202149/http://www.who.int/malaria/publications/atoz/9789241547925/en/index.html Guidelines for the treatment of malaria, second edition] Authors: WHO. Number of pages: 194. Publication date: 2010. Languages: English. {{ISBN|978-92-4-154792-5}}</ref> [[artemisinin-based combination therapies]] (ACTs) are the recommended [[first-line therapy|first-line]] [[antimalarial]] treatments for uncomplicated malaria caused by ''P. falciparum''. WHO recommends combinations such as [[artemether/lumefantrine]], [[artesunate/amodiaquine]], [[artesunate/mefloquine]], [[artesunate/sulfadoxine/pyrimethamine]], and [[dihydroartemisinin/piperaquine]].<ref name=who2010/>

The choice of ACT is based on the level of resistance to the constituents in the combination. Artemisinin and its derivatives are not appropriate for monotherapy. As a second-line antimalarial treatment, when initial treatment does not work, an alternative ACT known to be effective in the region is recommended, such as artesunate plus tetracycline or [[doxycycline]] or [[clindamycin]], and [[quinine]] plus tetracycline or doxycycline or clindamycin. Any of these combinations is to be given for 7 days. For pregnant women, the recommended first-line treatment during the [[first trimester]] is quinine plus clindamycin for 7 days.<ref name=who2010/> Artesunate plus clindamycin for 7 days is indicated if this treatment fails. For travellers returning to nonendemic countries, [[atovaquone]]/[[proguanil]], artemether/lumefantrineany and quinine plus doxycycline or clindamycin are recommended.<ref name=who2010/>