Editing Programmed cell death (section)

== Clinical significance ==

=== ABL ===

The BCR-ABL oncogene has been found to be involved in the development of [[cancer]] in humans.<ref name="srivastava2007">{{cite book|last=Srivastava|first=Rakesh|title=Apoptosis, Cell Signaling, and Human Diseases|year=2007|publisher=Humana Press}}</ref>

=== c-Myc ===

[[c-Myc]] is involved in the regulation of apoptosis via its role in downregulating the [[Bcl-2]] gene. Its role the disordered growth of tissue.<ref name="srivastava2007"/>

=== Metastasis ===

A [[molecular]] characteristic of metastatic cells is their altered expression of several apoptotic genes.<ref name="srivastava2007"/>