Editing Sequence alignment (section)

===Assessment of credibility===
Statistical significance indicates the probability that an alignment of a given quality could arise by chance, but does not indicate how much superior a given alignment is to alternative alignments of the same sequences.  Measures of alignment credibility indicate the extent to which the best scoring alignments for a given pair of sequences are substantially similar.  Methods of alignment credibility estimation for gapped sequence alignments are available in the literature.<ref name=NewbergLawrence2009>{{cite journal|author1=Newberg LA |author2=Lawrence CE | year=2009 | title=Exact Calculation of Distributions on Integers, with Application to Sequence Alignment | journal= J Comput Biol| volume=16| pages=1–18 | pmid = 19119992 | doi=10.1089/cmb.2008.0137| issue=1| pmc=2858568}}</ref>