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Sexual dysfunction
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====Menopause==== Estrogens are responsible for the maintenance of collagen, elastic fibers, and vasculature of the urogenital tract, all of which are important in maintaining vaginal structure and functional integrity; they are also important for maintaining vaginal pH and moisture levels, both of which help to keep the tissues lubricated and protected.<ref name="eden" /> Prolonged estrogen deficiency leads to atrophy, fibrosis, and reduced blood flow to the urogenital tract, which cause menopausal symptoms such as vaginal dryness and pain related to sexual activity and/or intercourse.<ref name="eden" /> Women experiencing vaginal dryness who cannot use commercial lubricants may be able to use coconut oil as an alternative.<ref>{{Cite journal |last1=Evangelista |first1=Mara Therese Padilla |last2=Abad-Casintahan |first2=Flordeliz |last3=Lopez-Villafuerte |first3=Lillian |date=January 2014 |title=The effect of topical virgin coconut oil on SCORAD index, transepidermal water loss, and skin capacitance in mild to moderate pediatric atopic dermatitis: a randomized, double-blind, clinical trial |journal=International Journal of Dermatology |language=en |volume=53 |issue=1 |pages=100β108 |doi=10.1111/ijd.12339|pmid=24320105 |doi-access=free }}</ref> Androgen therapy for hypoactive sexual desire disorder has a small benefit but its safety is not known.<ref name=Wri2015/> It is not approved as a treatment in the United States.<ref name=Wri2015>{{cite journal | vauthors = Wright JJ, O'Connor KM | title = Female sexual dysfunction | journal = The Medical Clinics of North America | volume = 99 | issue = 3 | pages = 607β628 | date = May 2015 | pmid = 25841603 | doi = 10.1016/j.mcna.2015.01.011 }}</ref> It is more commonly used among women who have had an oophorectomy or are in a postmenopausal state. However, like most treatments, this is also controversial. One study found that after a 24-week trial, women taking androgens had higher scores of sexual desire compared to a placebo group.<ref name="eden" /> As with all pharmacological drugs, there are side effects in using androgens, which include [[hirsutism]], acne, [[Polycythemia|polycythaemia]], increased high-density lipoproteins, cardiovascular risks, and [[endometrial hyperplasia]].<ref name="eden" /> Alternative treatments include topical estrogen creams and gels that can be applied to the vulva or vagina area to treat vaginal dryness and atrophy.<ref name="eden" />
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