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Cachexia
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==History== The word "cachexia" is derived from the Greek words "''Kakos''" (bad) and "''hexis''" (condition). English ophthalmologist [[John Zachariah Laurence]] was the first to use the phrase "cancerous cachexia", doing so in 1858. He applied the phrase to the chronic wasting associated with malignancy. It was not until 2011 that the term "cancer-associated cachexia" was given a formal definition, with a publication by [[Kenneth Fearon]]. Fearon defined it as "a multifactorial syndrome characterized by ongoing loss of skeletal muscle (with or without loss of fat mass) that cannot be fully reversed by conventional nutritional support and leads to progressive functional impairment".<ref name="Biswas">{{cite journal|doi=10.1146/annurev-cancerbio-030419-033642|doi-access=free|title=Cancer-Associated Cachexia: A Systemic Consequence of Cancer Progression|year=2020|last1=Biswas|first1=Anup K.|last2=Acharyya|first2=Swarnali|journal=Annual Review of Cancer Biology|volume=4|pages=391β411}}</ref>
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