Editing Cannabinoid (section)

==== 2-Arachidonoylglycerol (2-AG) ====
{{Main|2-Arachidonoylglycerol}}
Another endocannabinoid, 2-arachidonoylglycerol, binds to both the CB<sub>1</sub> and CB<sub>2</sub> receptors with similar affinity, acting as a full agonist at both.<ref name="grotenhermen 2005" /> 2-AG is present at significantly higher concentrations in the brain than anandamide,<ref name="stella 1997">{{cite journal | vauthors = Stella N, Schweitzer P, Piomelli D | title = A second endogenous cannabinoid that modulates long-term potentiation | journal = Nature | volume = 388 | issue = 6644 | pages = 773–778 | date = August 1997 | pmid = 9285589 | doi = 10.1038/42015 | type = Submitted manuscript | s2cid = 4422311 | doi-access = free | bibcode = 1997Natur.388..773S }}</ref> and there is some controversy over whether 2-AG rather than anandamide is chiefly responsible for endocannabinoid signalling ''[[in vivo]]''.<ref name="pmid16968947" /> In particular, one ''[[in vitro]]'' study suggests that 2-AG is capable of stimulating higher [[G-protein]] activation than anandamide, although the physiological implications of this finding are not yet known.<ref>{{cite journal | vauthors = Savinainen JR, Järvinen T, Laine K, Laitinen JT | title = Despite substantial degradation, 2-arachidonoylglycerol is a potent full efficacy agonist mediating CB(1) receptor-dependent G-protein activation in rat cerebellar membranes | journal = British Journal of Pharmacology | volume = 134 | issue = 3 | pages = 664–672 | date = October 2001 | pmid = 11588122 | pmc = 1572991 | doi = 10.1038/sj.bjp.0704297 }}</ref>