Editing Iron overload (section)

=== Neolithic ===
In the [[Neolithic era]], significant changes are thought to have occurred in both the environment and diet. Some communities of foragers migrated north, leading to changes in lifestyle and environment, with a decrease in temperatures and a change in the landscape which the foragers then needed to adapt to. As people began to develop and advance their tools, they learned new ways of producing food, and [[History of agriculture|farming also slowly developed]]. These changes would have led to serious stress on the body and a decrease in the consumption of iron-rich foods. This transition is a key factor in the mutation of genes, especially those that regulated dietary iron absorption. 70% of the body’s iron is found in the [[red blood cell|red blood cells]] and it is a critical [[micronutrient]] for effective [[thermoregulation]] in the body.<ref>{{Cite journal|last1=Rosenzweig|first1=P. H.|last2=Volpe|first2=S. L.|date=March 1999|title=Iron, thermoregulation, and metabolic rate|journal=Critical Reviews in Food Science and Nutrition|volume=39|issue=2|pages=131–148|doi=10.1080/10408399908500491|issn=1040-8398|pmid=10198751}}</ref> Iron deficiency will lead to a drop in the core temperature. In the chilly and damp environments of Northern Europe, supplementary iron from food was necessary to keep temperatures regulated, however, without sufficient iron intake the human body would have started to store iron at higher rates than normal. In theory, the pressures caused by migrating north would have selected for a [[gene mutation]] that promoted greater absorption and storage of iron.<ref>
{{Cite journal|last1=Heath|first1=Kathleen M.|last2=Axton|first2=Jacob H.|last3=McCullough|first3=John M.|last4=Harris|first4=Nathan|date=May 2016|title=The evolutionary adaptation of the C282Y mutation to culture and climate during the European Neolithic|journal=American Journal of Physical Anthropology|volume=160|issue=1|pages=86–101|doi=10.1002/ajpa.22937|issn=0002-9483|pmc=5066702|pmid=26799452}}
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