Open main menu
Home
Random
Recent changes
Special pages
Community portal
Preferences
About Wikipedia
Disclaimers
Incubator escapee wiki
Search
User menu
Talk
Dark mode
Contributions
Create account
Log in
Editing
Misconceptions about HIV/AIDS
(section)
Warning:
You are not logged in. Your IP address will be publicly visible if you make any edits. If you
log in
or
create an account
, your edits will be attributed to your username, along with other benefits.
Anti-spam check. Do
not
fill this in!
====AZT and other antiretroviral drugs, not HIV, cause AIDS==== {{Main|Duesberg hypothesis}} The vast majority of people with AIDS never received antiretroviral drugs, including those in developed countries prior to the licensure of [[Zidovudine|AZT]] in 1987. Even today, very few individuals in developing countries have access to these medications.<ref name="UNAIDS, 2003">[http://www.unaids.org/html/pub/publications/fact-sheets04/fs_treatment_en_pdf.pdf UNAIDS, 2003] {{webarchive|url=https://web.archive.org/web/20070614103019/http://www.unaids.org/html/pub/publications/fact-sheets04/fs_treatment_en_pdf.pdf |date=2007-06-14 }}</ref> In the 1980s, [[clinical trial]]s enrolling patients with AIDS found that AZT given as single-drug therapy conferred a survival advantage compared to [[placebo]], albeit modest and short-lived. Among HIV-infected patients who had not yet developed AIDS, placebo-controlled trials found that AZT given as a single-drug therapy delayed, for a year or two, the onset of AIDS-related illnesses. The lack of excess AIDS cases and death in the AZT arms of these placebo-controlled trials effectively counters the argument that AZT causes AIDS.<ref name="NIAID, 1995"/> Subsequent clinical trials found that patients receiving two-drug combinations had up to 50% increases in time to progression to AIDS and in survival when compared to people receiving single-drug therapy. In more recent years, three-drug combination therapies have produced another 50β80% improvements in progression to AIDS and in survival when compared to two-drug regimens in clinical trials.<ref name="HHS, 2005">{{Cite web |url=http://www.hivatis.org/guidelines/adult/AA_040705.pdf |title=HHS, 2005 |access-date=2005-08-23 |archive-url=https://web.archive.org/web/20171004135919/http://www.hivatis.org/guidelines/adult/AA_040705.pdf |archive-date=2017-10-04 |url-status=dead }}</ref> Use of potent anti-HIV combination therapies has contributed to dramatic reductions in the incidence of AIDS and AIDS-related deaths in populations where these drugs are widely available, an effect which would be unlikely if antiretroviral drugs ''caused'' AIDS.<ref name="Palella, 1998">{{cite journal | doi = 10.1056/NEJM199803263381301 | last1 = Palella | first1 = F.J. Jr | last2 = Delaney | first2 = K.M. | last3 = Moorman | first3 = A.C. | last4 = Loveless | first4 = M.O. | last5 = Fuhrer | first5 = J. | last6 = Satten | first6 = G.A. | last7 = Aschman | first7 = D.J. | last8 = Holmberg | first8 = S.D. | year = 1998 | title = Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators | journal = N. Engl. J. Med. | volume = 338 | issue = 13| pages = 853β60 | pmid = 9516219 | doi-access = free }}</ref><ref name="Mocroft, 1998">{{cite journal | doi = 10.1016/S0140-6736(98)03201-2 | last1 = Mocroft | first1 = A. | last2 = Vella | first2 = S. | last3 = Benfield | first3 = T.L. | last4 = Chiesi | first4 = A. | last5 = Miller | first5 = V. | last6 = Gargalianos | first6 = P. | last7 = Arminio Monforte | first7 = A. | last8 = Yust | first8 = I. | last9 = Bruun | first9 = J.N. | last10 = Phillips | first10 = AN | last11 = Lundgren | first11 = JD | year = 1998 | title = Changing patterns of mortality across Europe in patients infected with HIV-1. EuroSIDA Study Group | journal = Lancet | volume = 352 | issue = 9142| pages = 1725β30 | pmid = 9848347 | s2cid = 32223916 | display-authors = 9 }}</ref><ref name="Mocroft, 2000">{{cite journal | doi = 10.1016/S0140-6736(00)02504-6 | last1 = Mocroft | first1 = A. | last2 = Katlama | first2 = C. | last3 = Johnson | first3 = A.M. | last4 = Pradier | first4 = C. | last5 = Antunes | first5 = F. | last6 = Mulcahy | first6 = F. | last7 = Chiesi | first7 = A. | last8 = Phillips | first8 = A.N. | last9 = Kirk | first9 = O. | last10 = Lundgren | first10 = JD | year = 2000 | title = AIDS across Europe, 1994β98: the EuroSIDA study | journal = Lancet | volume = 356 | issue = 9226| pages = 291β96 | pmid = 11071184 | s2cid = 8167162 | display-authors = 9 }}</ref><ref name="Vittinghoff, 1999">{{cite journal | doi = 10.1086/314623 | last1 = Vittinghoff | first1 = E. | last2 = Scheer | first2 = S. | last3 = O'Malley | first3 = P. | last4 = Colfax | first4 = G. | last5 = Holmberg | first5 = S.D. | last6 = Buchbinder | first6 = S.P. | year = 1999 | title = Combination antiretroviral therapy and recent declines in AIDS incidence and mortality | journal = J. Infect. Dis. | volume = 179 | issue = 3| pages = 717β20 | pmid = 9952385 | doi-access = free }}</ref><ref name="Detels, 1998">{{cite journal | doi = 10.1001/jama.280.17.1497 | last1 = Detels | first1 = R. | last2 = Munoz | first2 = A. | last3 = McFarlane | first3 = G. | last4 = Kingsley | first4 = L.A. | last5 = Margolick | first5 = J.B. | last6 = Giorgi | first6 = J. | last7 = Schrager | first7 = L.K. | last8 = Phair | first8 = J.P. | year = 1998 | title = Effectiveness of potent antiretroviral therapy on time to AIDS and death in men with known HIV infection duration. Multicenter AIDS Cohort Study Investigators | journal = JAMA | volume = 280 | issue = 17| pages = 1497β503 | pmid = 9809730 | doi-access = free }}</ref><ref name="de Martino, 2000">{{cite journal | last1 = De Martino | first1 = M | last2 = Tovo | first2 = PA | last3 = Balducci | first3 = M | last4 = Galli | first4 = L | last5 = Gabiano | first5 = C | last6 = Rezza | first6 = G | last7 = Pezzotti | first7 = P | title = Reduction in mortality with availability of antiretroviral therapy for children with perinatal HIV-1 infection. Italian Register for HIV Infection in Children and the Italian National AIDS Registry | journal = JAMA | volume = 284 | issue = 2 | pages = 190β97 | year = 2000 | pmid = 10889592 | doi=10.1001/jama.284.2.190| doi-access = free }}</ref><ref name="Hogg, 1999">{{cite journal | last1 = Hogg | first1 = R.S. | last2 = Yip | first2 = B. | last3 = Kully | first3 = C. | last4 = Craib | first4 = K.J. | last5 = O'Shaughnessy | first5 = M.V. | last6 = Schechter | first6 = M.T. | last7 = Montaner | first7 = J.S. | year = 1999 | title = Improved survival among HIV-infected patients after initiation of triple-drug antiretroviral regimens | journal = CMAJ | volume = 160 | issue = 5| pages = 659β65 | pmid = 10102000 | pmc = 1230111 }}</ref><ref name="Schwarcz, 2000">{{cite journal | doi = 10.1093/aje/152.2.178 | last1 = Schwarcz | first1 = S.K. | last2 = Hsu | first2 = L.C. | last3 = Vittinghoff | first3 = E. | last4 = Katz | first4 = M.H. | year = 2000 | title = Impact of protease inhibitors and other antiretroviral treatments on acquired immunodeficiency syndrome survival in San Francisco, California, 1987β1996 | journal = Am. J. Epidemiol. | volume = 152 | issue = 2| pages = 178β85 | pmid = 10909955 | doi-access = free }}</ref><ref name="Kaplan, 2000">{{cite journal | last1 = Kaplan | first1 = JE | last2 = Hanson | first2 = D | last3 = Dworkin | first3 = MS | last4 = Frederick | first4 = T | last5 = Bertolli | first5 = J | last6 = Lindegren | first6 = ML | last7 = Holmberg | first7 = S | last8 = Jones | first8 = JL | title = Epidemiology of human immunodeficiency virus-associated opportunistic infections in the United States in the era of highly active antiretroviral therapy | journal = Clinical Infectious Diseases | volume = 30 | pages = S5βS14 | year = 2000 | issue = Suppl 1 | pmid = 10770911 | doi = 10.1086/313843 | doi-access = free }}</ref><ref name="McNaghten, 1999">{{cite journal | doi = 10.1097/00002030-199909100-00012 | last1 = McNaghten | first1 = A.D. | last2 = Hanson | first2 = D.L. | last3 = Jones | first3 = J.L. | last4 = Dworkin | first4 = M.S. | last5 = Ward | first5 = J.W. | last6 = The Adultadolescent Spectrum Of Disease Group +/ | year = 1999 | title = Effects of antiretroviral therapy and opportunistic illness primary chemoprophylaxis on survival after AIDS diagnosis. Adult/Adolescent Spectrum of Disease Group | journal = AIDS | volume = 13 | issue = 13| pages = 1687β95 | pmid = 10509570 | doi-access = free }}</ref>{{citation overkill|date=January 2021}}
Edit summary
(Briefly describe your changes)
By publishing changes, you agree to the
Terms of Use
, and you irrevocably agree to release your contribution under the
CC BY-SA 4.0 License
and the
GFDL
. You agree that a hyperlink or URL is sufficient attribution under the Creative Commons license.
Cancel
Editing help
(opens in new window)