Editing Quorum sensing (section)

====Interaction of quorum-sensing molecules with mammalian cells and its medical applications====
Next to the potential antimicrobial functionality, quorum-sensing derived molecules, especially the peptides, are being investigated for their use in other therapeutic domains as well, including immunology, central nervous system disorders and oncology. Quorum-sensing peptides have been demonstrated to interact with cancer cells, as well as to permeate the blood–brain barrier reaching the brain parenchyma.<ref>{{cite journal | vauthors = De Spiegeleer B, Verbeke F, D'Hondt M, Hendrix A, Van De Wiele C, Burvenich C, Peremans K, De Wever O, Bracke M, Wynendaele E | display-authors = 6 | title = The quorum sensing peptides PhrG, CSP and EDF promote angiogenesis and invasion of breast cancer cells in vitro | journal = PLOS ONE | volume = 10 | issue = 3 | pages = e0119471 | year = 2015 | pmid = 25780927 | pmc = 4363635 | doi = 10.1371/journal.pone.0119471 | bibcode = 2015PLoSO..1019471D | doi-access = free }}</ref><ref>{{cite journal | vauthors = Wynendaele E, Verbeke F, D'Hondt M, Hendrix A, Van De Wiele C, Burvenich C, Peremans K, De Wever O, Bracke M, De Spiegeleer B | display-authors = 6 | title = Crosstalk between the microbiome and cancer cells by quorum sensing peptides | journal = Peptides | volume = 64 | pages = 40–48 | date = February 2015 | pmid = 25559405 | doi = 10.1016/j.peptides.2014.12.009 | hdl-access = free | s2cid = 28064836 | hdl = 2263/59248 }}</ref><ref>{{cite journal | vauthors = Wynendaele E, Verbeke F, Stalmans S, Gevaert B, Janssens Y, Van De Wiele C, Peremans K, Burvenich C, De Spiegeleer B | display-authors = 6 | title = Quorum Sensing Peptides Selectively Penetrate the Blood-Brain Barrier | journal = PLOS ONE | volume = 10 | issue = 11 | pages = e0142071 | date = Nov 2015 | pmid = 26536593 | pmc = 4633044 | doi = 10.1371/journal.pone.0142071 | bibcode = 2015PLoSO..1042071W | doi-access = free }}</ref>