Editing Cachexia (section)

==Research==
Several medications are under investigation or have been previously trialed for use in cachexia but are currently not in widespread clinical use:

* [[Thalidomide]]<ref name="Argiles"/>
* Cytokine antagonists<ref name="epcrc-2010" />
* [[Cannabinoids]]<ref name=epcrc-2010 /> 
* [[Omega-3 fatty acid]]s, including [[eicosapentaenoic acid]] (EPA)<ref name=epcrc-2010 /><ref name=Ries-2012>{{cite journal | vauthors = Ries A, Trottenberg P, Elsner F, Stiel S, Haugen D, Kaasa S, Radbruch L | title = A systematic review on the role of fish oil for the treatment of cachexia in advanced cancer: an EPCRC cachexia guidelines project | journal = Palliative Medicine | volume = 26 | issue = 4 | pages = 294–304 | date = June 2012 | pmid = 21865295 | doi = 10.1177/0269216311418709 | s2cid = 2801425 | url = https://opus4.kobv.de/opus4-fau/files/3468/ries_systematic.pdf }}</ref> 
* [[Non-steroidal anti-inflammatory drug]]s<ref name=epcrc-2010 /> 
* [[Prokinetic]]s<ref name=epcrc-2010 />  
* [[Ghrelin]] and [[ghrelin receptor]] agonist<ref name=Ebner-2013 /> 
* Anabolic catabolic transforming agents such as MT-102<ref name=Ebner-2013 /> 
* [[Selective androgen receptor modulator]]s<ref name=Ebner-2013 />
* [[Cyproheptadine]]<ref name="Suzuki-2013">{{cite journal | vauthors = Suzuki H, Asakawa A, Amitani H, Nakamura N, Inui A | title = Cancer cachexia--pathophysiology and management | journal = Journal of Gastroenterology | volume = 48 | issue = 5 | pages = 574–94 | date = May 2013 | pmid = 23512346 | pmc = 3698426 | doi = 10.1007/s00535-013-0787-0 }}</ref> 
* [[Hydrazine sulfate]]<ref name=Suzuki-2013 />

[[Medical marijuana]] has been allowed for the treatment of cachexia in some US states, such as Missouri, Illinois, Maryland, Delaware, Nevada, Michigan, Washington, Oregon, California, Colorado, New Mexico, Arizona, Vermont, New Jersey, Rhode Island, Maine, and New York <ref>{{Cite web|url=https://www.health.ny.gov/regulations/medical_marijuana/about.htm|title=Program Information and News - New York State Medical Marijuana Program|website=www.health.ny.gov}}</ref><ref>[http://www.maine.gov/dhhs/dlrs/mmm/documents/MMMP-Rules-144c122.pdf Rules Governing the Maine Medical Use of Marijuana Program] {{Webarchive|url=https://web.archive.org/web/20141112003735/http://www.maine.gov/dhhs/dlrs/mmm/documents/MMMP-Rules-144c122.pdf |date=2014-11-12 }} - 10-144 CMR Chapter 122 - Section 3.1.3</ref> Hawaii<ref>{{Cite web|url=http://health.hawaii.gov/medicalmarijuanaregistry/providers/debilitating-medical-conditions/|title=Medical Marijuana Registry Program {{!}} Eligible Debilitating Medical Conditions|website=health.hawaii.gov|access-date=2016-04-27|archive-url=https://web.archive.org/web/20160522062325/http://health.hawaii.gov/medicalmarijuanaregistry/providers/debilitating-medical-conditions/|archive-date=2016-05-22|url-status=dead}}</ref> and Connecticut.<ref name=Gagnon>{{cite journal | vauthors = Gagnon B, Bruera E | title = A review of the drug treatment of cachexia associated with cancer | journal = Drugs | volume = 55 | issue = 5 | pages = 675–88 | date = May 1998 | pmid = 9585863 | doi = 10.2165/00003495-199855050-00005 | s2cid = 22180434 }}</ref><ref>{{cite journal | vauthors = Yavuzsen T, Davis MP, Walsh D, LeGrand S, Lagman R | title = Systematic review of the treatment of cancer-associated anorexia and weight loss | journal = Journal of Clinical Oncology | volume = 23 | issue = 33 | pages = 8500–11 | date = November 2005 | pmid = 16293879 | doi = 10.1200/JCO.2005.01.8010 }}</ref>

===Multimodal therapy===
Despite the extensive investigation into single therapeutic targets for cachexia, the most effective treatments use multi-targeted therapies. In Europe, a combination of non-drug approaches including physical training, nutritional counseling, and [[psychotherapeutic]] intervention are used in belief this approach may be more effective than monotherapy.<ref name="epcrc-2010">{{cite web|url=http://www.epcrc.org/guidelines.php?p=cachexia|title=New European Guidelines: Clinical Practice Guidelines on Cancer Cachexia in Advanced Cancer Patients|publisher=European Palliative Care Research Collaborative|url-status=dead|archive-url=https://web.archive.org/web/20140502215044/http://www.epcrc.org/guidelines.php?p=cachexia|archive-date=2 May 2014|access-date=23 February 2014}}</ref> Administration of anti-inflammatory drugs showed efficacy and safety in the treatment of people with advanced cancer  cachexia.<ref name="Argiles">{{cite journal | vauthors = Argilés JM, Busquets S, López-Soriano FJ | title = Anti-inflammatory therapies in cancer cachexia | journal = European Journal of Pharmacology | volume = 668 | pages = S81–6 | date = September 2011 | issue = Suppl 1 | pmid = 21835173 | doi = 10.1016/j.ejphar.2011.07.007 }}</ref>