Editing Epigenetics (section)

====Nanopore sequencing====
Certain sequencing methods, such as [[nanopore sequencing]], allow sequencing of native DNA. Native (=unamplified) DNA retains the epigenetic modifications which would otherwise be lost during the amplification step. Nanopore basecaller models can distinguish between the signals obtained for epigenetically modified bases and unaltered based and provide an epigenetic profile in addition to the sequencing result.<ref>{{cite journal | vauthors = Simpson JT, Workman RE, Zuzarte PC, David M, Dursi LJ, Timp W | title = Detecting DNA cytosine methylation using nanopore sequencing | journal = Nature Methods | volume = 14 | issue = 4 | pages = 407–410 | date = April 2017 | pmid = 28218898 | doi = 10.1038/nmeth.4184 | s2cid = 16152628 }}</ref>