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Hideyo Noguchi
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=== Successes in tropical diseases === Noguchi began to tackle Rocky mountain spotted fever, similar to another disease [[Tsutsugamuchi disease|Tsutsugamushi]] present in Japan, where deaths were common among rice planters and farmers.<ref name=":9">{{Cite book |last=Eckstein |first=Gustav |title=Noguchi |publisher=Harper |year=1931 |pages=236}}</ref><ref>{{Cite book |last=Kita |first=Atsushi |title=Dr. Noguchi's Journey: A Life of Medical Search and Discovery. |date=July 1, 2005 |publisher=Kodansha USA |pages=201}}</ref> Furthermore, he began researching [[jaundice]] after two Japanese scientists announced a discovery of a spirochete appearing in the liver of a guinea pig demonstrating jaundice.<ref>{{Cite journal |last=Otteraaen |first=Andrew |date=1919 |title=The Spirochete of Infectious Jaundice (Spiro- Chets Icterohemorrhagiae, Inada; Lep -Tospira, Noguchi) in House Rats in Chicago |journal=John McCormick Institute for Infectious Disease |volume=24 |issue=5 |pages=485β488 |doi=10.1093/infdis/24.5.485}}</ref> In June of 1918, Noguchi became chief investigator on a commission of the [[Rockefeller Foundation|International Health Board]] traveled throughout Central America and South America to conduct research to develop a [[vaccine]] for yellow fever.<ref>{{Cite journal |last=Tan |first=Siang |date=2014 |title=Hideyo Noguchi (1876β1928): Distinguished bacteriologist |journal=Singapore Medical Journal |volume=55 |issue=10 |pages=550β551 |doi=10.11622/smedj.2014140 |pmc=4293967 |pmid=25631898}}</ref><ref name=":39" /> He once said, "Whether I succeed or not is another matter, but the problem is worth trying." Noguchi dabbled in researching numerous diseases at the same time. He felt one might get results.<ref name=":9" /> In 1921, he was elected as a member of the [[American Philosophical Society]].<ref>{{Cite web |title=APS Member History |url=https://search.amphilsoc.org/memhist/search?creator=Noguchi&title=&subject=&subdiv=&mem=&year=&year-max=&dead=&keyword=&smode=advanced |access-date=2021-05-03 |website=search.amphilsoc.org}}</ref> In the meantime, Noguchi published a revision of ''Serum Diagnosis of Syphilis'' with assistance from [[Evelyn Butler Tilden|Evelyn Tilden]] in 1922, ''Laboratory Diagnosis of Syphilis'', which aided in the diagnosis and treatment of the disease.<ref>Plesset, Isabel (1980). ''Noguchi and his Patrons''. Fairleigh Dickinson University Press. p. 225</ref><ref name=":38" /> In 1923, Noguchi had attempted creating passive and active immunity for Rocky mountain spotted fever.<ref name=":38" /> One of his close assistants died during the research, which he mourned. He supported his assistants widow and children. <ref name=":0" /> He made a breakthrough when he produced the first antiserum for the disease to render partial immunity.<ref name=":42">{{Cite book |last=Eckstein |first=Gustav |title=Noguchi |publisher=Harper |year=1931 |pages=235}}</ref> During his time in Peru and Ecuador, between 1925 to 1927, he worked on Carrions disease and verruca peruana, which was widespread in the regions, and proved the infections were due to the same species, ''Bartonella bacilliformis.<ref name=":55" />''[[File:Dr.Noguchi Hideyo - The Rockefeller Institute for Medical Research, New York - 1927 - Suzuki Rakan Seisaku.png|thumb|Hideyo Noguchi in his Rockefeller laboratory ]]His assistant, Akatsu, noted Noguchi showed discontent in his career even with recent breakthroughs.<ref name=":8">{{Cite book |last=Eckstein |first=Gustav |title=Noguchi |publisher=Harper |year=1931 |publication-date=1931 |pages=243}}</ref><ref>{{Cite book |last=Kita |first=Atsushi |title=Dr. Noguchi's Journey: A Life of Medical Search and Discovery. |publisher=Kodansha USA |date=July 1, 2005 |pages=200}}</ref> Noguchi sometimes lost his temper and scolding his assistants, but outside of the laboratory, Noguchi was a different and more open person. He would invite him to restaurants and speak Japanese{{snd}}something he never did at the Rockefeller Institute.<ref name=":6" /> In a letter to Flexner, he wrote,<blockquote> "Somehow I cannot manage to find enough time to sit quietly and think over things calmly and reflect upon many things and phases in life. I seem to be chasing something all the time, perhaps an acquired habit or rather the lack of poise".<ref>{{Cite web |last=Mehl |first=Margaret |date=March 16, 2023 |title=From Fukushima to Ghana: Noguchi Hideyo, the Peasant Boy Who Made It |url=https://margaretmehl.com/from-fukushima-to-ghana-noguchi-hideyo-the-peasant-boy-who-made-it-3/#_edn2 |access-date=August 29, 2024 |website=Margaret Mehl}}</ref></blockquote>
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