Editing Notch signaling pathway (section)

=== Bone development ===

Early ''in vitro'' studies have found the Notch signaling pathway functions as down-regulator in [[osteoclast]]ogenesis and [[osteoblast]]ogenesis.<ref>{{cite journal | vauthors = Yamada T, Yamazaki H, Yamane T, Yoshino M, Okuyama H, Tsuneto M, Kurino T, Hayashi S, Sakano S | display-authors = 6 | title = Regulation of osteoclast development by Notch signaling directed to osteoclast precursors and through stromal cells | journal = Blood | volume = 101 | issue = 6 | pages = 2227–2234 | date = March 2003 | pmid = 12411305 | doi = 10.1182/blood-2002-06-1740 | doi-access = free }}</ref> Notch1 is expressed in the mesenchymal condensation area and subsequently in the hypertrophic [[chondrocytes]] during chondrogenesis.<ref>{{cite journal | vauthors = Watanabe N, Tezuka Y, Matsuno K, Miyatani S, Morimura N, Yasuda M, Fujimaki R, Kuroda K, Hiraki Y, Hozumi N, Tezuka K | display-authors = 6 | title = Suppression of differentiation and proliferation of early chondrogenic cells by Notch | journal = Journal of Bone and Mineral Metabolism | volume = 21 | issue = 6 | pages = 344–352 | year = 2003 | pmid = 14586790 | doi = 10.1007/s00774-003-0428-4 | s2cid = 1881239 }}</ref> Overexpression of Notch signaling inhibits bone morphogenetic protein2-induced osteoblast differentiation. Overall, Notch signaling has a major role in the commitment of mesenchymal cells to the osteoblastic lineage and provides a possible therapeutic approach to bone regeneration.<ref name="pmid15695512" />