Editing Polyphenol (section)

=== Phlebotonic ===
{{Main|Diosmin#Phlebotonics}}
Phlebotonics of heterogeneous composition, consisting partly of [[Peel (fruit)|citrus peel]] [[extract]]s ([[flavonoid]]s, such as [[hesperidin]]) and synthetic compounds, are used to treat [[chronic venous insufficiency]] and [[hemorrhoid]]s.<ref name="drugs">{{cite web |date=1 January 2019 |title=Diosmin |url=https://www.drugs.com/npp/diosmin.html |access-date=7 November 2019 |publisher=Drugs.com}}</ref> Some are [[Prescription drug|non-prescription]] [[dietary supplement]]s, such as [[diosmin]],<ref name="drugs" /> while one other – Vasculera (Diosmiplex) – is a prescription [[medical food]] intended for treating venous disorders.<ref name="dailymed-diosmiplex">{{cite web |date=26 April 2012 |title=Vasculera – diosmiplex tablet |url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=563d3d34-a547-471e-aecd-f4a4a57cbf1d |access-date=8 November 2019 |website=dailymed.nlm.nih.gov |publisher=National Institutes of Health}}</ref> Their mechanism of action is undefined,<ref name="drugs" /> and [[Evidence-based medicine|clinical evidence]] of benefit for using phlebotonics to treat venous diseases is limited.<ref name="drugs" />