Editing Vancomycin (section)

=== "Regained" vancomycin ===
In 2020 a team at the [[University Hospital Heidelberg]] (Germany) regained vancomycin's antibacterial power by modifying the molecule with a cationic [[oligopeptide]]. The oligopeptide consists of six [[arginin]] units in Position V<sub>N</sub>. In comparison to the unmodified vancomycin the activity against vancomycin-resistant bacteria could be enhanced by a factor of 1,000.<ref name="pmid32190958">{{cite journal | vauthors = Umstätter F, Domhan C, Hertlein T, Ohlsen K, Mühlberg E, Kleist C, Zimmermann S, Beijer B, Klika KD, Haberkorn U, Mier W, Uhl P | title = Vancomycin Resistance Is Overcome by Conjugation of Polycationic Peptides | journal = Angewandte Chemie | volume = 59 | issue = 23 | pages = 8823–8827 | date = June 2020 | pmid = 32190958 | pmc = 7323874 | doi = 10.1002/anie.202002727 }}</ref><ref name="mw-EP">{{cite patent | inventor = Mier W, Umstätter F, Uhl P, Domhan C | url = https://patents.google.com/patent/EP3846854A2/en | title = Improved polypeptide coupled antibiotics. | country = EP | number = 3846854A2 | pridate = 4 September 2019 }} {{Webarchive|url=https://web.archive.org/web/20211008071101/https://patents.google.com/patent/EP3846854A2/en |date=8 October 2021 }}</ref> This pharmacon is still in [[preclinical development]].