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Folate
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===Canada=== Canadian public health efforts focused on promoting awareness of the importance of folic acid supplementation for all women of childbearing age and decreasing socio-economic inequalities by providing practical folic acid support to vulnerable groups of women.<ref>{{cite web|url=http://www.hc-sc.gc.ca|title=Welcome to the Health Canada Web site|publisher=Hc-sc.gc.ca|access-date=9 September 2012|url-status=live|archive-url=https://web.archive.org/web/20120910203617/http://www.hc-sc.gc.ca/|archive-date=10 September 2012}}</ref> Folic acid [[food fortification]] became mandatory in 1998, with the fortification of 150 ΞΌg of folic acid per 100 grams of [[enriched flour]] and uncooked [[cereal]] grains.<ref name=Mason2007>{{cite journal|vauthors=Mason JB, Dickstein A, Jacques PF, Haggarty P, Selhub J, Dallal G, Rosenberg IH|title=A temporal association between folic acid fortification and an increase in colorectal cancer rates may be illuminating important biological principles: a hypothesis|journal=Cancer Epidemiology, Biomarkers & Prevention|volume=16|issue=7|pages=1325β9|date=July 2007|pmid=17626997|doi=10.1158/1055-9965.EPI-07-0329|doi-access=free}}</ref> The results of folic acid fortification on the rate of neural tube defects in [[Canada]] have been positive, showing a 46% reduction in prevalence of NTDs; the magnitude of reduction was proportional to the prefortification rate of NTDs, essentially removing geographical variations in rates of NTDs seen in Canada before fortification.<ref>{{cite journal|vauthors=De Wals P, Tairou F, Van Allen MI, Uh SH, Lowry RB, Sibbald B, Evans JA, Van den Hof MC, Zimmer P, Crowley M, Fernandez B, Lee NS, Niyonsenga T|title=Reduction in neural-tube defects after folic acid fortification in Canada|journal=The New England Journal of Medicine|volume=357|issue=2|pages=135β42|date=July 2007|pmid=17625125|doi=10.1056/NEJMoa067103|doi-access=free}}</ref>
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