Editing Platelet (section)

===PFA-100===
The [[PFA-100]] (Platelet Function Assay — 100) is a system for analysing platelet function in which citrated whole blood is aspirated through a disposable cartridge containing an aperture within a membrane coated with either collagen and epinephrine or collagen and ADP. These agonists induce platelet adhesion, activation and aggregation, leading to rapid occlusion of the aperture and cessation of blood flow termed the closure time (CT). An elevated CT with EPI and collagen can indicate intrinsic defects such as [[von Willebrand disease]], [[uremia]], or circulating platelet inhibitors. A follow-up test involving collagen and ADP is used to indicate if the abnormal CT with collagen and EPI was caused by the effects of acetyl sulfosalicylic acid (aspirin) or medications containing inhibitors.<ref>{{cite web |url=http://www.pathology.vcu.edu/media/pathology/clinical/coag/PFA-100FAQ.pdf |title=Platelet Function Assay FAQ |website=Department of Pathology |publisher=Virginia Commonwealth University |access-date=2017-03-27}}</ref> The PFA-100 is highly sensitive to von Willebrand disease, but is only moderately sensitive to defects in platelet function.<ref>{{cite journal |vauthors=Favaloro EJ, Pasalic L, Lippi G |title=Towards 50 years of platelet function analyser (PFA) testing |journal=Clin Chem Lab Med |volume=61 |issue=5 |pages=851–860 |date=April 2023 |pmid=35859143 |doi=10.1515/cclm-2022-0666 }}</ref>