Editing Tissue engineering (section)

==== Tissue engineering ''in situ'' ====
''In situ'' tissue regeneration is defined as the implantation of biomaterials (alone or in combination with cells and/or biomolecules) into the tissue defect, using the surrounding microenvironment of the organism as a natural bioreactor.<ref>{{Cite journal |last1=Dias |first1=Juliana R. |last2=Ribeiro |first2=Nilza |last3=Baptista-Silva |first3=Sara |last4=Costa-Pinto |first4=Ana Rita |last5=Alves |first5=Nuno |last6=Oliveira |first6=Ana L. |date=2020 |title=In situ Enabling Approaches for Tissue Regeneration: Current Challenges and New Developments |journal=Frontiers in Bioengineering and Biotechnology |volume=8 |pages=85 |doi=10.3389/fbioe.2020.00085 |issn=2296-4185 |pmc=7039825 |pmid=32133354 |doi-access=free }}</ref> This approach has found application in bone regeneration,<ref>{{Cite journal |last1=Malek-Khatabi |first1=A. |last2=Javar |first2=H.A. |last3=Dashtimoghadam |first3=E. |last4=Ansari |first4=S. |last5=Hasani-Sadrabadi |first5=M.M. |last6=Moshaverinia |first6=A. |date=2020 |title=In situ bone tissue engineering using gene delivery nanocomplexes |url=https://pubmed.ncbi.nlm.nih.gov/32160962 |journal=Acta Biomaterialia |volume=108 |pages=326–336 |doi=10.1016/j.actbio.2020.03.008 |issn=1878-7568 |pmid=32160962|s2cid=212679291 }}</ref> allowing the formation of cell-seeded constructs directly in the operating room.<ref>{{Cite journal |last1=Krasilnikova |first1=O.A. |last2=Baranovskii |first2=D.S. |last3=Yakimova |first3=A.O. |last4=Arguchinskaya |first4=N. |last5=Kisel |first5=A. |last6=Sosin |first6=D. |last7=Sulina |first7=Y. |last8=Ivanov |first8=S.A. |last9=Shegay |first9=P.V. |last10=Kaprin |first10=A.D. |last11=Klabukov |first11=I.D. |date=2022 |title=Intraoperative Creation of Tissue-Engineered Grafts with Minimally Manipulated Cells: New Concept of Bone Tissue Engineering In Situ |journal=Bioengineering  |volume=9 |issue=11 |pages=704 |doi=10.3390/bioengineering9110704 |issn=2306-5354 |pmc=9687730 |pmid=36421105 |doi-access=free }}</ref>