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=== Computational biology === {{main|DNA annotation}} Since the 1980s, [[molecular biology]] and [[bioinformatics]] have created the need for [[DNA annotation]]. DNA annotation or genome annotation is the process of identifying the locations of genes and all of the coding regions in a genome and determining what those genes do. An annotation (irrespective of the context) is a note added by way of explanation or commentary. Once a genome is sequenced, it needs to be annotated to make sense of it.<ref>{{Cite web|title=Medical Definition of Genome annotation|url=https://www.medicinenet.com/genome_annotation/definition.htm|access-date=2021-09-09|website=MedicineNet|language=en}}</ref>
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