Editing Cannabinoid (section)

==== Virodhamine (OAE) ====
{{Main|Virodhamine}}
A fifth endocannabinoid, virodhamine, or ''O''-arachidonoyl-ethanolamine (OAE), was discovered in June 2002. Although it is a full [[agonist]] at CB<sub>2</sub> and a partial agonist at CB<sub>1</sub>, it behaves as a CB<sub>1</sub> antagonist ''[[in vivo]]''. In rats, virodhamine was found to be present at comparable or slightly lower concentrations than [[anandamide]] in the [[brain]], but 2- to 9-fold higher concentrations peripherally.<ref>{{cite journal | vauthors = Porter AC, Sauer JM, Knierman MD, Becker GW, Berna MJ, Bao J, Nomikos GG, Carter P, Bymaster FP, Leese AB, Felder CC | display-authors = 6 | title = Characterization of a novel endocannabinoid, virodhamine, with antagonist activity at the CB1 receptor | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 301 | issue = 3 | pages = 1020–1024 | date = June 2002 | pmid = 12023533 | doi = 10.1124/jpet.301.3.1020 | url = http://pdfs.semanticscholar.org/ab53/846ea9f65d5a673d2e4552933c2a26409b00.pdf | url-status = dead | s2cid = 26156181 | archive-url = https://web.archive.org/web/20190303094035/http://pdfs.semanticscholar.org/ab53/846ea9f65d5a673d2e4552933c2a26409b00.pdf | archive-date = 2019-03-03 }}</ref>